Patient P-02106

Synthetic patientMETA-24 · Day 178 · 75+ · F · baseline S14Steering view · 3D Open companion preview

Therapy response

Declining

Tolerance

Deteriorating

GI state

Stable

Inflammatory state

Unstable

Nutritional resilience

Unstable

Discontinuation risk

70%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 META-24 started — Baseline state S14
Day 47 NP-02 recommended — Dietary Support Protocol NP-02
Day 48 Patient accepted — Started NP-02 in the companion
Day 58 No meaningful change — Dietary Support Protocol NP-02
Day 68 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 80 GI-04 recommended — GI Support Protocol GI-04
Day 81 Patient accepted — Started GI-04 in the companion
Day 89 GI symptom burden −30% vs expected — GI Support Protocol GI-04
Day 95 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 68.

Primary contributors, last 14 days

Inflammatory activity+9
Toxicity+9
Nutritional resilience-8
Treatment adherence-8

What helped?

Dietary Support Protocol NP-02Day 47
Result: no meaningful change
GI Support Protocol GI-04Day 80
Result: symptom burden −30%

LIFE OS recommendation

Monitoring Escalation ME-01

83%

probability of meaningful tolerance improvement

284 similar trajectories
100% showed improvement
median effect visible after 3 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

Active minutes

Wearable

1 min

worsening · -1.7 vs previous 14 d

Sleep duration

Wearable

6.1 h

stable · +0.2 vs previous 14 d

Energy level

Daily log

2.8/10

stable · -0.0 vs previous 14 d

Steps

Wearable

918

stable · -63 vs previous 14 d

GI burden

Companion

54.5/100

improving · -3.1 vs previous 14 d

Adherence

Companion

46.6 %

stable · -1.2 vs previous 14 d

Sleep quality

Wearable

29.5/100

improving · +4.0 vs previous 14 d

Glucose, CGM daily mean

CGM

137 mg/dL

stable · -4.6 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 26 from the failing basin, 62 from restoration.

Would help

ME-01 Monitoring Escalation
100% improved among 42 similar · onset 3 d · confidence 71%
SC-12 Supportive Compound
69% improved among 26 similar · onset 6 d · confidence 71%
CR-01 Clinician Review
100% improved among 6 similar · onset 5 d · confidence 71%
More protein
GI -6.2 next day on high-intake days · n 19

Would not help

NP-02 Dietary Support Protocol
already tried, no meaningful change
Keep histamine low
GI +4.7 next day on high-intake days · n 23
Keep fat low
GI +3.8 next day on high-intake days · n 19
Keep fibre low
GI +3.3 next day on high-intake days · n 27

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Protein
-6.2supporter · 95%
Histamine load
+4.7detractor · 95%
Dietary fat load
+3.8detractor · 95%
Insoluble fibre
+3.3detractor · 82%
Ultra-processed food
+3.1detractor · 80%
Simple carbohydrates
+1.8no signal · 41%
Alcohol
+0.2no signal · 15%
Caffeine
-0.1no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 55 and rising
- WearableSleep 6.1 h, below personal baseline
Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 32/100
- Daily logFibre intake low in recent food logs
Inflammatory signalling ↑45
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 59
Autonomic recovery ↑40
- Wearable918 steps/day
- WearableShort sleep window
Drug metabolism and exposure ↑20
- BloodToxicity index 51

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
CYP2D6 Normal metabolizer
Expected exposure
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 2.8 · butyrate capacity 32/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiNormal
Bacteroides fragilisHigh
Bifidobacterium longumLow
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 42 ms
Sleep: 6.3 h
Steps: 2,776
Resting HR: 69 bpm

Daily log: GI score 55, nutritional resilience 38, adherence 47.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Eat slowly and stop at comfortable fullness — smaller volume, more often

What to do

Track each bowel movement today: time, stool form, urgency, overnight waking
A 15-minute walk after lunch
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the dose at the same time relative to your evening meal
Electrolyte solution, one sachet after any loose stool
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-02255	59%	S14	GI-04	improved	43
P-02401	56%	S14	GI-04	improved	49
P-02316	55%	S14	GI-04	improved	51
P-02018	51%	S01	GI-04	improved	46
P-02328	51%	S14	GI-04	improved	42
P-02103	49%	S14	GI-04	improved	46
P-02168	48%	S15	GI-04	improved	42
P-02326	48%	S18	NP-02	improved	44
P-02002	47%	S14	GI-04	improved	47
P-02504	47%	S14	GI-04	improved	52
P-02185	46%	S14	GI-04	improved	51
P-02348	46%	S14	GI-04	improved	49