Patient P-02218
Synthetic patientMETA-24 · Day 174 · 25–34 · F · baseline S01Steering view · 3DOpen companion preview
Therapy response
Favorable
Tolerance
Improving
GI state
Improving
Inflammatory state
Improving
Nutritional resilience
Favorable
Discontinuation risk
10%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S01
- Day 15 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 22 DT-01 recommended — Dosing / Timing Recommendation DT-01
- Day 23 Patient accepted — Started DT-01 in the companion
- Day 28 GI symptom burden −27% vs expected — Dosing / Timing Recommendation DT-01
- Day 34 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 15.
Primary contributors, last 14 days
- Toxicity-19
- Inflammatory activity-12
- GI instability-6
- Treatment adherence-5
- Nutritional resilience+2
What helped?
- Dosing / Timing Recommendation DT-01Day 22Result: symptom burden −27%
LIFE OS recommendation
No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Active minutes
Wearable37 min
worsening · -8.0 vs previous 14 d
Sleep duration
Wearable6.7 h
stable · +0.2 vs previous 14 d
Energy level
Daily log6.1/10
worsening · -0.4 vs previous 14 d
Steps
Wearable5,008
worsening · -749 vs previous 14 d
GI burden
Companion18.6/100
worsening · +6.1 vs previous 14 d
Adherence
Companion93.2 %
stable · -2.2 vs previous 14 d
Sleep quality
Wearable54.3/100
stable · +1.4 vs previous 14 d
Glucose, CGM daily mean
CGM127 mg/dL
stable · +2.4 vs previous 14 d
This trajectory is doing well — what to keep, what to watch
Steering view →Heading towards restoration · 77 from the failing basin, 17 from restoration.
Good elements to keep
- Dosing / Timing Recommendation DT-01intervention · steering +18.5
- Protein (supports)perturbation · steering +9
- Proteinsupporter · GI -4.7 next day
Main detractors to watch
- Low butyrate capacityhidden · steering -17.5
- Poor metabolizerhidden · steering -12.7
- FUT2 non-secretorhidden · steering -10.6
- Ultra-processed foodperturbation · steering -9.9
- Ultra-processed fooddetractor · GI +5.4 next day
- Histamine loaddetractor · GI +5.2 next day
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Ultra-processed food+5.4detractor · 95%
- Histamine load+5.2detractor · 95%
- Caffeine+5.2detractor · 95%
- Dietary fat load+4.7detractor · 95%
- Protein-4.7supporter · 95%
- Simple carbohydrates+4.4detractor · 95%
- Insoluble fibre-0.3no signal · 15%
- Alcohol+0.3no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 27/100
- MicrobiomeF. prausnitzii depleted
- Drug metabolism and exposure ↑40
- DNACYP2D6 poor metabolizer → higher exposure
- Inflammatory signalling ↓25
- DNAIL6 -174 variant raises baseline inflammatory tone
- Autonomic recovery ↑25
- WearableResting HR 74 bpm
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Poor metabolizerHigher exposure at standard dose
Microbiome
Shannon diversity 2.8 · butyrate capacity 27/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 47 ms
- Sleep
- 6.5 h
- Steps
- 3,853
- Resting HR
- 76 bpm
Daily log: GI score 19, nutritional resilience 66, adherence 93.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Log the daily check-in; one line is enough
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.