Patient P-02218

Synthetic patientMETA-24 · Day 174 · 25–34 · F · baseline S01Steering view · 3D Open companion preview

Therapy response

Favorable

Tolerance

Improving

GI state

Improving

Inflammatory state

Improving

Nutritional resilience

Favorable

Discontinuation risk

10%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 META-24 started — Baseline state S01
Day 15 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 22 DT-01 recommended — Dosing / Timing Recommendation DT-01
Day 23 Patient accepted — Started DT-01 in the companion
Day 28 GI symptom burden −27% vs expected — Dosing / Timing Recommendation DT-01
Day 34 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 15.

Primary contributors, last 14 days

Toxicity-19
Inflammatory activity-12
GI instability-6
Treatment adherence-5
Nutritional resilience+2

What helped?

Dosing / Timing Recommendation DT-01Day 22
Result: symptom burden −27%

LIFE OS recommendation

No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

Active minutes

Wearable

37 min

worsening · -8.0 vs previous 14 d

Sleep duration

Wearable

6.7 h

stable · +0.2 vs previous 14 d

Energy level

Daily log

6.1/10

worsening · -0.4 vs previous 14 d

Steps

Wearable

5,008

worsening · -749 vs previous 14 d

GI burden

Companion

18.6/100

worsening · +6.1 vs previous 14 d

Adherence

Companion

93.2 %

stable · -2.2 vs previous 14 d

Sleep quality

Wearable

54.3/100

stable · +1.4 vs previous 14 d

Glucose, CGM daily mean

CGM

127 mg/dL

stable · +2.4 vs previous 14 d

This trajectory is doing well — what to keep, what to watch

Steering view →

Heading towards restoration · 77 from the failing basin, 17 from restoration.

Good elements to keep

Dosing / Timing Recommendation DT-01
intervention · steering +18.5
Protein (supports)
perturbation · steering +9
Protein
supporter · GI -4.7 next day

Main detractors to watch

Low butyrate capacity
hidden · steering -17.5
Poor metabolizer
hidden · steering -12.7
FUT2 non-secretor
hidden · steering -10.6
Ultra-processed food
perturbation · steering -9.9
Ultra-processed food
detractor · GI +5.4 next day
Histamine load
detractor · GI +5.2 next day

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Ultra-processed food
+5.4detractor · 95%
Histamine load
+5.2detractor · 95%
Caffeine
+5.2detractor · 95%
Dietary fat load
+4.7detractor · 95%
Protein
-4.7supporter · 95%
Simple carbohydrates
+4.4detractor · 95%
Insoluble fibre
-0.3no signal · 15%
Alcohol
+0.3no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 27/100
- MicrobiomeF. prausnitzii depleted
Drug metabolism and exposure ↑40
- DNACYP2D6 poor metabolizer → higher exposure
Inflammatory signalling ↓25
- DNAIL6 -174 variant raises baseline inflammatory tone
Autonomic recovery ↑25
- WearableResting HR 74 bpm

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Poor metabolizer
Higher exposure at standard dose

Microbiome

Shannon diversity 2.8 · butyrate capacity 27/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisNormal
Bifidobacterium longumLow
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 47 ms
Sleep: 6.5 h
Steps: 3,853
Resting HR: 76 bpm

Daily log: GI score 19, nutritional resilience 66, adherence 93.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Keep meals regular; three to four moderate portions spaced through the day
Include a cooked vegetable portion with each main meal
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Eat slowly and stop at comfortable fullness — smaller volume, more often

What to do

Log the daily check-in; one line is enough
Keep the current walking rhythm
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the dose at the same time relative to your evening meal
No additional supplements this week
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-02645	52%	S02	HY-01	improved	56
P-02697	50%	S07	GI-04	improved	56
P-02303	46%	S15	GI-04	improved	48
P-02033	45%	S06	GI-04	improved	51
P-02235	45%	S14	DT-01	improved	50
P-02586	45%	S18	DT-01	improved	56
P-02602	45%	S20	HY-01	improved	52
P-02147	44%	S13	GI-04	improved	58
P-02355	44%	S09	GI-04	improved	55
P-02479	44%	S13	DT-01	improved	48
P-02538	44%	S02	GI-04	improved	59
P-02126	43%	S16	DT-01	improved	59