Patient P-02395

Synthetic patientMETA-24 · Day 170 · 35–44 · M · baseline S12Steering view · 3D Open companion preview

Therapy response

Improving

Tolerance

Favorable

GI state

Deteriorating

Inflammatory state

Deteriorating

Nutritional resilience

Declining

Discontinuation risk

35%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 META-24 started — Baseline state S12
Day 16 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 22 DT-01 recommended — Dosing / Timing Recommendation DT-01
Day 23 Patient accepted — Started DT-01 in the companion
Day 28 GI symptom burden −15% vs expected — Dosing / Timing Recommendation DT-01
Day 34 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 16.

Primary contributors, last 14 days

Inflammatory activity+12
GI instability+11
Nutritional resilience-8
Treatment adherence+5

What helped?

Dosing / Timing Recommendation DT-01Day 22
Result: symptom burden −15%

LIFE OS recommendation

Dietary Support Protocol NP-02

41%

probability of meaningful tolerance improvement

284 similar trajectories
50% showed improvement
median effect visible after 10 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

Active minutes

Wearable

41 min

stable · +0.8 vs previous 14 d

Sleep duration

Wearable

6.9 h

stable · +0.1 vs previous 14 d

Energy level

Daily log

5.9/10

improving · +0.7 vs previous 14 d

Steps

Wearable

4,086

stable · +104 vs previous 14 d

GI burden

Companion

36.5/100

improving · -5.9 vs previous 14 d

Adherence

Companion

97.2 %

stable · +0.7 vs previous 14 d

Sleep quality

Wearable

45.3/100

stable · +1.8 vs previous 14 d

Glucose, CGM daily mean

CGM

136 mg/dL

stable · -4.1 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 54 from the failing basin, 33 from restoration.

Would help

No untried action with strong evidence. Compose one from primitives.
More protein
GI -4 next day on high-intake days · n 15

Would not help

Keep ultra-processed low
GI +3.7 next day on high-intake days · n 18
Keep histamine low
GI +3.5 next day on high-intake days · n 20
Keep fat low
GI +2.6 next day on high-intake days · n 21

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Protein
-4supporter · 95%
Ultra-processed food
+3.7detractor · 95%
Histamine load
+3.5detractor · 95%
Dietary fat load
+2.6detractor · 95%
Simple carbohydrates
+1.9detractor · 65%
Caffeine
-1.2no signal · 36%
Insoluble fibre
+0.2no signal · 15%
Alcohol
0no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 43/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
CYP2D6 Intermediate metabolizer
Expected exposure

Microbiome

Shannon diversity 2.6 · butyrate capacity 43/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisNormal
Bifidobacterium longumNormal
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 66 ms
Sleep: 7.2 h
Steps: 3,957
Resting HR: 66 bpm

Daily log: GI score 37, nutritional resilience 50, adherence 97.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Keep meals regular; three to four moderate portions spaced through the day
Include a cooked vegetable portion with each main meal
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Eat slowly and stop at comfortable fullness — smaller volume, more often

What to do

Log the daily check-in; one line is enough
A 15-minute walk after lunch
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the dose at the same time relative to your evening meal
No additional supplements this week
Fictional demo item: oral nutrition supplement with lunch

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-02093	31%	S05	AD-05	no change	40
P-02483	37%	S06	BR-03	no change	64
P-02087	33%	S01	BR-03	no change	40
P-02280	31%	S07	BR-03	no change	50
P-02267	30%	S09	BR-03	no change	45
P-02439	30%	S08	BR-03	no change	40
P-02522	30%	S01	BR-03	no change	40
P-02233	31%	S16	CR-01	improved	66
P-02641	41%	S05	DT-01	no change	45
P-02339	39%	S03	DT-01	improved	50
P-02274	38%	S15	DT-01	improved	50
P-02417	38%	S18	DT-01	no change	55