Patient P-02459
Therapy response
Declining
Tolerance
Improving
GI state
Deteriorating
Inflammatory state
Favorable
Nutritional resilience
Declining
Discontinuation risk
49%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S05
- Day 14 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 22 HY-01 recommended — Hydration Protocol HY-01
- Day 23 Patient accepted — Started HY-01 in the companion
- Day 27 GI symptom burden −28% vs expected — Hydration Protocol HY-01
- Day 33 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 14.
Primary contributors, last 14 days
- GI instability+21
- Toxicity-14
- Nutritional resilience-8
- Treatment adherence-4
- Inflammatory activity-3
What helped?
- Hydration Protocol HY-01Day 22Result: symptom burden −28%
LIFE OS recommendation
Dosing / Timing Recommendation DT-01
57%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 75% showed improvement
- median effect visible after 5 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓35
- MicrobiomeButyrate capacity 34/100
- Mucosal barrier integrity ↓30
- MicrobiomeAkkermansia low → thinner mucus layer
- Inflammatory signalling ↓20
- MicrobiomeBacteroides fragilis expansion
- Autonomic recovery ↓20
- Wearable3,077 steps/day
DNA
Fictional pharmacogenomic panel
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 1.9 · butyrate capacity 34/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 48 ms
- Sleep
- 7.2 h
- Steps
- 3,332
- Resting HR
- 56 bpm
Daily log: GI score 39, nutritional resilience 58, adherence 92.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Log the daily check-in; one line is enough
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02485 | 44% | S05 | HY-01 | improved | 63 |
| P-02538 | 44% | S02 | GI-04 | improved | 59 |
| P-02150 | 43% | S11 | HY-01 | improved | 45 |
| P-02223 | 43% | S20 | HY-01 | improved | 49 |
| P-02339 | 43% | S03 | DT-01 | improved | 50 |
| P-02033 | 42% | S06 | GI-04 | improved | 51 |
| P-02037 | 42% | S04 | GI-04 | improved | 53 |
| P-02235 | 42% | S14 | DT-01 | improved | 50 |
| P-02414 | 42% | S13 | HY-01 | improved | 58 |
| P-02685 | 42% | S16 | DT-01 | improved | 47 |
| P-02303 | 41% | S15 | GI-04 | improved | 48 |
| P-02599 | 41% | S14 | HY-01 | improved | 54 |