Patient P-02577

Synthetic patientMETA-24 · Day 103 · 65–74 · F · baseline S10Steering view · 3D Open companion preview

Therapy response

Stable

Tolerance

Favorable

GI state

Deteriorating

Inflammatory state

Favorable

Nutritional resilience

Declining

Discontinuation risk

31%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 META-24 started — Baseline state S10
Day 22 Trajectory diverged from prediction — Observed response fell below the model's expected path.

What changed?

Trajectory began diverging from predicted response on Day 22.

Primary contributors, last 14 days

Treatment adherence-11
Nutritional resilience-5
GI instability+4
Toxicity+4

What helped?

No interventions yet.

LIFE OS recommendation

Dietary Support Protocol NP-02

35%

probability of meaningful tolerance improvement

284 similar trajectories
50% showed improvement
median effect visible after 10 days

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

Active minutes

Wearable

37 min

stable · 0.0 vs previous 14 d

Sleep duration

Wearable

7.7 h

stable · -0.1 vs previous 14 d

Energy level

Daily log

5.5/10

worsening · -0.3 vs previous 14 d

Steps

Wearable

4,400

stable · +93 vs previous 14 d

GI burden

Companion

35.4/100

worsening · +5.3 vs previous 14 d

Adherence

Companion

86.9 %

stable · +1.5 vs previous 14 d

Sleep quality

Wearable

52.9/100

stable · -1.5 vs previous 14 d

Glucose, CGM daily mean

CGM

133 mg/dL

stable · +4.9 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 56 from the failing basin, 31 from restoration.

Would help

No untried action with strong evidence. Compose one from primitives.
More protein
GI -7.2 next day on high-intake days · n 25

Would not help

Keep caffeine low
GI +7.6 next day on high-intake days · n 18
Keep histamine low
GI +7.5 next day on high-intake days · n 21

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Caffeine
+7.6detractor · 95%
Histamine load
+7.5detractor · 95%
Protein
-7.2supporter · 95%
Insoluble fibre
-4no signal · 54%
Ultra-processed food
-2.3no signal · 41%
Alcohol
+1.7no signal · 19%
Dietary fat load
+0.9no signal · 15%
Simple carbohydrates
-0.2no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
Drug metabolism and exposure ↑40
- DNACYP2D6 poor metabolizer → higher exposure
Butyrate / short-chain fatty acid production ↓25
- MicrobiomeF. prausnitzii depleted

DNA

Fictional pharmacogenomic panel

FUT2 rs601338 AA (non-secretor)
Reduced mucosal fucosylation
CYP2D6 Poor metabolizer
Higher exposure at standard dose
GLP1R rs6923761 A
Altered receptor sensitivity

Microbiome

Shannon diversity 3.3 · butyrate capacity 47/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiLow
Bacteroides fragilisNormal
Bifidobacterium longumNormal
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 42 ms
Sleep: 7.5 h
Steps: 5,247
Resting HR: 67 bpm

Daily log: GI score 35, nutritional resilience 51, adherence 87.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Keep meals regular; three to four moderate portions spaced through the day
Include a cooked vegetable portion with each main meal
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Eat slowly and stop at comfortable fullness — smaller volume, more often

What to do

Log the daily check-in; one line is enough
A 15-minute walk after lunch
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the dose at the same time relative to your evening meal
No additional supplements this week
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-02093	30%	S05	AD-05	no change	40
P-02285	30%	S14	AD-05	no change	39
P-02483	45%	S06	BR-03	no change	64
P-02280	35%	S07	BR-03	no change	50
P-02267	34%	S09	BR-03	no change	45
P-02087	33%	S01	BR-03	no change	40
P-02354	35%	S01	CR-01	improved	78
P-02233	32%	S16	CR-01	improved	66
P-02491	50%	S09	DT-01	no change	65
P-02518	41%	S17	DT-01	improved	68
P-02274	40%	S15	DT-01	improved	50
P-02462	39%	S12	DT-01	improved	65