DeepGene damage signature
SyntheticSynthetic demo data2 samples: baseline day 0 · retest day 90
Damage score · retest day 90
68/100
vs baseline (day 0)
+1
5 improved · 5 worsened
synthetic signature · consistent with this patient's biology
- 2 opportunists above range: Streptococcus gallolyticus, Clostridioides difficile
- 4 keystone species absent
- Shannon 2.38 (expected ≥ 3)
- 8 resistance genes
- Host DNA fragmentation atypical
- Tissue recycling index 46
Pathogens / opportunists2/5
↓ from 3
Keystone species4/8
Diversity2/2
↑ from 1
Metabolic modules0/4
↓ from 1
Vitamin synthesis3/7
Oral translocation1/1
Host DNA1/1
↑ from 0
Tissue recycling1/1
Central mechanisms0/2
↓ from 2
Virulence factors4/4
Antibiotic resistance genes8/8
↑ from 6
Genetic predisposition2/2
Opportunists above range
Streptococcus gallolyticus 1.953% AR
Clostridioides difficile 1.953% AR
Keystone species absent
Akkermansia muciniphila, Bifidobacterium longum, Butyricicoccus pullicaecorum, Eubacterium rectale
Capacity
Shannon 2.38 · butyrate 570 CPM · SCFA 997
3 vitamins below
Host & mechanisms
host DNA fragmentation atypical
tissue recycling 46/100
oral translocation 4.45% AR
8 resistance genes · 4 virulence factors
Import a sample
A baseline sample re-initializes this patient's microbiome, pathways and predispositions from the measurement; a retest adds a comparison and updates them. Every theory, steering gain and dietary sensitivity downstream is then conditioned on the measured signature.
All elements · baseline → latest
Value, status vs the expected range, and the implication on health. Changes coloured: green improved / resolved, red worsened / new.
Pathogens / opportunists · 5
| Escherichia coli | 0.378 % AR · in range | 0.351 % AR · in range | expected <= 1% | In excess raises LPS load and zonulin release, opening tight junctions. |
| Klebsiella pneumoniae | 6.214 % AR · above range | 0.034 % AR · in range(improved) | expected <= 0.3% | Opportunist above range; relevant after antibiotics and in inflammation. |
| Enterococcus faecium | 10.357 % AR · above range | 0.065 % AR · in range(improved) | expected <= 0.5% | Opportunist above range; relevant after antibiotics and in inflammation. |
| Streptococcus gallolyticus | 0.006 % AR · in range | 1.953 % AR · above range(worsened) | expected <= 0.1% | Opportunist above range; relevant after antibiotics and in inflammation. |
| Clostridioides difficile | 2.071 % AR · above range | 1.953 % AR · above range | expected <= 0.1% | Opportunist above range; relevant after antibiotics and in inflammation. |
Keystone species · 8
| Akkermansia muciniphila | 0 % AR · absent | 0 % AR · absent | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Bifidobacterium longum | 0 % AR · absent | 0 % AR · absent | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Butyricicoccus pullicaecorum | 0 % AR · absent | 0 % AR · absent | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Eubacterium rectale | 0 % AR · absent | 0 % AR · absent | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Faecalibacterium prausnitzii | 0.3 % AR · in range | 1.23 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Lactobacillus species | 1.26 % AR · in range | 1.45 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Roseburia intestinalis | 1.35 % AR · in range | 0.62 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Ruminococcus bromii | 0.96 % AR · in range | 1.09 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
Diversity · 2
| indice Shannon | 2.57 · below range | 2.38 · below range | expected >= 3.0 | Low diversity: fewer reserve metabolic routes, slower recovery after perturbation. |
| numar de specii detectate | 104 specii · in range | 99 specii · below range(worsened) | expected >= 100 | Species count below reference. |
Metabolic modules · 4
| Butyrate production | 519 CPM · in range | 570 CPM · in range | expected 255.83-1089.91 CPM | Butyrate is the main colonocyte fuel and barrier signal. |
| Short Chain Fatty Acid Production | 930 CPM · in range | 997 CPM · in range | expected 535.03-1572.59 CPM | Total SCFA capacity. |
| GABA production | 314 CPM · in range | 294 CPM · in range | expected 87.31-766.53 CPM | Gut–brain axis capacity. |
| H2S production (sulfate reduction) | 450 CPM · above range | 108 CPM · in range(improved) | expected banda de referinta | Hydrogen sulfide above band irritates the mucosa. |
Vitamin synthesis · 7
| Vitamin B1 - Thiamin | 160 CPM · below range | 402 CPM · below range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B2 - Riboflavin | 433 CPM · below range | 359 CPM · below range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B5 - Pantothenic acid | 239 CPM · below range | 175 CPM · below range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B6 - Pyridoxine | 3559 CPM · in range | 3891 CPM · in range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B7 - Biotin | 3624 CPM · in range | 4314 CPM · in range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B9 - Folate | 2834 CPM · in range | 4289 CPM · in range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B12 - Cobalamin | 3755 CPM · in range | 3853 CPM · in range | expected 2000-5000 CPM | Microbial synthesis capacity. |
Oral translocation · 1
| Translocare orala (indice) | 4.71 % AR · above range | 4.45 % AR · above range | expected <= 2% | Oral taxa in stool: reduced gastric barrier or dysbiosis. |
Host DNA · 1
| fragmentare mixta | 156 pb · in range | 243 pb · atypical(worsened) | expected 150-170 pb | Host cell-free DNA fragmentation pattern. |
Tissue recycling · 1
| indice de reciclare tisulara | 46 /100 · above range | 46 /100 · above range | expected < 35 | Epithelial turnover. |
Central mechanisms · 2
| molecular_mimicry | 69 /100 · above range | 65 /100 · in range(improved) | expected < 65 | Cross-reactive antigen load. |
| estrobolome | 68 /100 · above range | 63 /100 · in range(improved) | expected < 65 | Estrogen-recycling capacity. |
Virulence factors · 4
| fimD outer membrane usher | 21 potriviri/M · present | 84 potriviri/M · present | expected absent | Virulence factor detected. |
| chuA heme/hemoglobin receptor | 53 potriviri/M · present | 33 potriviri/M · present | expected absent | Virulence factor detected. |
| irp2 yersiniabactin synthetase | 22 potriviri/M · present | 73 potriviri/M · present | expected absent | Virulence factor detected. |
| espX4 type III secretion | 27 potriviri/M · present | 46 potriviri/M · present | expected absent | Virulence factor detected. |
Antibiotic resistance genes · 8
| sul1 | 9.7 citiri/M · present | 10.8 citiri/M · present | expected nedetectat | Resistance gene detected. |
| sul2 | 4 citiri/M · present | 9.3 citiri/M · present | expected nedetectat | Resistance gene detected. |
| tet(O/M/O) | 10.9 citiri/M · present | 6.1 citiri/M · present | expected nedetectat | Resistance gene detected. |
| Ecol_ampC_BLA | 8.1 citiri/M · present | 8.1 citiri/M · present | expected nedetectat | Resistance gene detected. |
| aadA | 9.9 citiri/M · present | 4.5 citiri/M · present | expected nedetectat | Resistance gene detected. |
| dfrA1 | 1.8 citiri/M · present | 7.2 citiri/M · present | expected nedetectat | Resistance gene detected. |
| APH(6)-Id | — | 10.4 citiri/M · present(new) | expected nedetectat | Resistance gene detected. |
| Erm(49) | — | 10.9 citiri/M · present(new) | expected nedetectat | Resistance gene detected. |
Genetic predisposition · 2
| IL6 | 2.93 OR · risk variant | 2.73 OR · risk variant | expected reference genotype | Higher inflammatory tone |
| CYP2D6 | 2.37 OR · risk variant | 2.19 OR · risk variant | expected reference genotype | Expected exposure |