Patient P-01308
Therapy response 78 at the day-84 endpoint (observed).
Responding: response probability 77%, therapy response 77 today; biology is not blocking the drug.
Drift detected on day 13 (HRV −10 ms, resting HR +4 bpm, sleep −1.1 h, gi toxicity +24, inflammatory load +24); the side effect would have been reported on day 17 — 4 days of warning.
8 of 8 scheduled doses in the last 60 days are biologically confirmed (100%). Dose signature: resting HR +3 bpm, HRV −11 ms.
Trajectory is stable relative to similar patients; keep the current content.
- 🍽Keep meals regular; three to four moderate portions spaced through the day
- 🍽Include a cooked vegetable portion with each main meal
- ✓Log the daily check-in; one line is enough
- ✓A 15-minute walk after lunch
- 💊Take the scheduled dose as agreed with your care team
- 💊No additional supplements this week
Adherence is not the problem.
sleep quality falling under 35 while GI rises
P-01308 is on day 111 of NBL-101 (EC-02, baseline S16): response favorable, tolerance favorable, GI improving. Over 14 days response moved 0 and GI -14; discontinuation risk is 2%. The state is in the restoration basin, heading towards restoration, after diverging from the model on day 13.
Biology sets the gain: IL6 high-expression variant; butyrate capacity 79/100, diversity 3.0. Pushing it down: Bacteroides fragilis elevated (-11.5), IL6 high-expression variant (-11.4), Simple carbohydrates (-7.8). Pulling it up: Butyrate producers intact (+11.6). From the daily log: simple carbs +2.8 GI next day.
No action has been tried yet.
No action is indicated now; the trajectory is stable relative to similar patients.
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and events- Day 0 NBL-101 started — Baseline state S16
- Day 13 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 13.
- GI instability-14
- Inflammatory activity-10
- Nutritional resilience+9
- Treatment adherence+2
What helped?
No interventions yet.
Daily trackers
Asset settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Heading towards restoration · 97 from the failing basin, 15 from restoration.
- Butyrate producers intacthidden · steering +11.6
- Bacteroides fragilis elevatedhidden · steering -11.5
- IL6 high-expression varianthidden · steering -11.4
- Simple carbohydratesperturbation · steering -7.8
- Dietary driftperturbation · steering -2.6
- Simple carbohydratesdetractor · GI +2.8 next day
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Simple carbohydrates+2.8detractor · 59%
- Alcohol+1.8no signal · 34%
- Spicy / capsaicin+1.7no signal · 34%
- Histamine load+1no signal · 16%
- Dietary fat load+0.7no signal · 15%
- Insoluble fibre+0.4no signal · 15%
DeepGene damage signature
The metagenomic + host-DNA read-out that initializes this patient's biology and, on retest, measures whether the steering worked.
- 1 keystone species absent
- 3 resistance genes
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
- Inflammatory signalling ↓45
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- Mucosal barrier integrity ↓30
- MicrobiomeAkkermansia low → thinner mucus layer
- Butyrate / short-chain fatty acid production ↓25
- MicrobiomeF. prausnitzii depleted
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Normal metabolizerExpected exposure
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
- HRV
- 71 ms
- Sleep
- 6.8 h
- Steps
- 5,305
- Resting HR
- 60 bpm
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
- Log the daily check-in; one line is enough
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01481 | 40% | S15 | AD-05 | no change | 67 |
| P-01468 | 27% | S03 | AD-05 | no change | 50 |
| P-01450 | 26% | S18 | AD-05 | no change | 45 |
| P-01411 | 46% | S13 | BR-03 | no change | 76 |
| P-01489 | 40% | S05 | BR-03 | improved | 83 |
| P-01764 | 39% | S15 | BR-03 | no change | 85 |
| P-01766 | 35% | S01 | BR-03 | improved | 83 |
| P-01664 | 43% | S07 | CR-01 | improved | 85 |
| P-01896 | 41% | S06 | CR-01 | improved | 73 |
| P-01472 | 44% | S20 | DT-01 | no change | 82 |
| P-01428 | 39% | S18 | DT-01 | improved | 82 |
| P-01528 | 33% | S20 | DT-01 | improved | 89 |