Patient P-01432
Therapy response
Declining
Tolerance
Favorable
GI state
Favorable
Inflammatory state
Favorable
Nutritional resilience
Stable
Discontinuation risk
49%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S14
- Day 44 SC-12 recommended — Supportive Compound SC-12
- Day 45 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 45 Patient accepted — Started SC-12 in the companion
- Day 51 GI symptom burden −24% vs expected — Supportive Compound SC-12
- Day 52 GI-04 recommended — GI Support Protocol GI-04
- Day 53 Patient accepted — Started GI-04 in the companion
- Day 57 Tolerance state changed — Unstable → Improving
- Day 61 GI symptom burden −39% vs expected — GI Support Protocol GI-04
- Day 67 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 45.
Primary contributors, last 14 days
- Treatment adherence+8
- Inflammatory activity-2
- Toxicity+2
What helped?
- Supportive Compound SC-12Day 44Result: symptom burden −24%
- GI Support Protocol GI-04Day 52Result: symptom burden −39%
LIFE OS recommendation
Adherence Support AD-05
30%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 20% showed improvement
- median effect visible after 5 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 35/100
- MicrobiomeF. prausnitzii depleted
- Inflammatory signalling ↓20
- MicrobiomeBacteroides fragilis expansion
DNA
Fictional pharmacogenomic panel
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 2.4 · butyrate capacity 35/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 55 ms
- Sleep
- 7.7 h
- Steps
- 9,064
- Resting HR
- 70 bpm
Daily log: GI score 33, nutritional resilience 59, adherence 57.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Log the daily check-in; one line is enough
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01377 | 34% | S11 | AD-05 | no change | 42 |
| P-01483 | 33% | S14 | AD-05 | no change | 35 |
| P-01679 | 31% | S12 | AD-05 | no change | 39 |
| P-01541 | 30% | S09 | AD-05 | no change | 43 |
| P-01804 | 28% | S19 | AD-05 | improved | 61 |
| P-01689 | 32% | S13 | BR-03 | no change | 50 |
| P-01313 | 29% | S01 | BR-03 | improved | 32 |
| P-01350 | 29% | S19 | BR-03 | no change | 34 |
| P-01450 | 28% | S09 | BR-03 | no change | 36 |
| P-01430 | 32% | S05 | CR-01 | improved | 54 |
| P-01371 | 29% | S06 | CR-01 | improved | 63 |
| P-01342 | 30% | S11 | DT-01 | improved | 48 |