Patient P-01432
Therapy response 43 at the day-84 endpoint (observed).
Responding: response probability 47%, therapy response 47 today; biology is not blocking the drug.
Drift detected on day 47 (resting HR +5 bpm, gi toxicity +15, inflammatory load +5); the side effect would have been reported on day 55 — 8 days of warning.
8 of 9 scheduled doses in the last 60 days are biologically confirmed (89%). Dose signature: resting HR +6 bpm, HRV −11 ms.
Adherence is 56% and stable; nothing else works if the dose is missed → adherence support first.
33% of 284 similar trajectories improved after AD-05; if this one does, discontinuation risk is expected to fall from 55% to ~38%. Keeping histamine low is worth 3.7 GI points a day on its own. Losing this patient costs €57k; the intervention costs €180.
- 🍽Keep meals regular; three to four moderate portions spaced through the day
- 🍽Include a cooked vegetable portion with each main meal
- ✓Log the daily check-in; one line is enough
- ✓A 15-minute walk after lunch
- 💊Take the scheduled dose as agreed with your care team
- 💊No additional supplements this week
Dose is being missed; nothing else works until this is fixed.
adherence still under 65% after 7 days
P-01432 is on day 103 of NBL-101 (EC-03, baseline S14): response declining, tolerance favorable, GI improving. Over 14 days response moved -10 and GI -4; discontinuation risk is 55%. The state is between basins, heading towards failing, after diverging from the model on day 47.
Biology sets the gain: FUT2 non-secretor, Poor metabolizer, Low butyrate capacity, Low microbial diversity, Baseline state S14, Cluster EC-03 (high response / high intolerance), Adherence < 60%; butyrate capacity 34/100, diversity 2.7. Pushing it down: Escherichia coli 30.739% (LPS load) (-32.8), Low butyrate capacity (-25.8), 6 keystone species absent (-19.3). Pulling it up: GI Support Protocol GI-04 (+41.1), Supportive Compound SC-12 (+31). From the daily log: histamine +3.7 GI next day, fat +3.5 GI next day, simple carbs +3.3 GI next day.
Past actions: NP-02 on day 32 → no change (2%); SC-12 on day 48 → improved (19%); GI-04 on day 57 → improved (28%).
Next: AD-05 — 33% of 284 similar trajectories improved, 33% probability here. Adherence is 56% and stable; nothing else works if the dose is missed → adherence support first. This would be contradicted by a further GI rise within the onset window or falling adherence.
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and events- Day 0 NBL-101 started — Baseline state S14
- Day 31 NP-02 recommended — Dietary Support Protocol NP-02
- Day 32 Patient accepted — Started NP-02 in the companion
- Day 42 No meaningful change — Dietary Support Protocol NP-02
- Day 47 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 47 SC-12 recommended — Supportive Compound SC-12
- Day 48 Patient accepted — Started SC-12 in the companion
- Day 54 GI symptom burden −19% vs expected — Supportive Compound SC-12
- Day 56 GI-04 recommended — GI Support Protocol GI-04
- Day 57 Patient accepted — Started GI-04 in the companion
- Day 60 Tolerance state changed — Unstable → Improving
- Day 65 GI symptom burden −28% vs expected — GI Support Protocol GI-04
- Day 71 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 47.
- Nutritional resilience+7
- GI instability-4
- Toxicity+3
- Treatment adherence-2
What helped?
- Dietary Support Protocol NP-02Day 31Result: no meaningful change
- Supportive Compound SC-12Day 47Result: symptom burden −19%
- GI Support Protocol GI-04Day 56Result: symptom burden −28%
- 284 similar trajectories
- 33% showed improvement
- median effect visible after 5 days
Adherence is 56% and stable; nothing else works if the dose is missed → adherence support first.
Daily trackers
Asset settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Heading towards failing · 47 from the failing basin, 41 from restoration.
- NP-02 Dietary Support Protocolalready tried, no meaningful change
- Keep histamine lowGI +3.7 next day on high-intake days · n 20
- Keep fat lowGI +3.5 next day on high-intake days · n 19
- Keep simple carbs lowGI +3.3 next day on high-intake days · n 19
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Histamine load+3.7detractor · 95%
- Dietary fat load+3.5detractor · 95%
- Simple carbohydrates+3.3detractor · 95%
- Alcohol-0.7no signal · 16%
- Insoluble fibre-0.6no signal · 16%
- Spicy / capsaicin0no signal · 15%
DeepGene damage signature
The metagenomic + host-DNA read-out that initializes this patient's biology and, on retest, measures whether the steering worked.
- 4 opportunists above range: Escherichia coli, Klebsiella pneumoniae, Enterococcus faecium
- 6 keystone species absent
- Shannon 1.89 (expected ≥ 3)
- 10 resistance genes
- Tissue recycling index 56
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
- Autonomic recovery ↑65
- WearableResting HR 74 bpm
- Wearable3,305 steps/day
- WearableShort sleep window
- Mucosal barrier integrity ↓40
- DNAFUT2 non-secretor lowers mucosal fucosylation
- WearableSleep 5.9 h, below personal baseline
- Drug metabolism and exposure ↑40
- DNACYP2D6 poor metabolizer → higher exposure
- Butyrate / short-chain fatty acid production ↓35
- MicrobiomeButyrate capacity 34/100
- Inflammatory signalling ↓20
- MicrobiomeBacteroides fragilis expansion
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Poor metabolizerHigher exposure at standard dose
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
- HRV
- 53 ms
- Sleep
- 6.2 h
- Steps
- 4,294
- Resting HR
- 75 bpm
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
- Log the daily check-in; one line is enough
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01897 | 33% | S01 | SC-12 | improved | 49 |
| P-01706 | 32% | S01 | NP-02 | improved | 42 |
| P-01746 | 31% | S01 | NP-02 | improved | 40 |
| P-01877 | 27% | S01 | CR-01 | improved | 61 |
| P-01724 | 26% | S01 | SC-12 | no change | 60 |
| P-01725 | 25% | S01 | CR-01 | improved | 62 |
| P-01748 | 25% | S01 | — | — | 67 |
| P-01858 | 25% | S01 | ME-01 | improved | 41 |
| P-01684 | 24% | S01 | — | — | 64 |
| P-01800 | 24% | S01 | — | — | 36 |
| P-01713 | 42% | S02 | GI-04 | improved | 50 |
| P-01407 | 34% | S02 | GI-04 | improved | 43 |