Patient P-01479
Therapy response 75 at the day-84 endpoint (observed).
Responding: response probability 79%, therapy response 80 today; biology is not blocking the drug.
Drift detected on day 17 (HRV −9 ms, resting HR +5 bpm, sleep −2.1 h, gi toxicity +36, inflammatory load +34); the side effect would have been reported on day 20 — 3 days of warning.
8 of 9 scheduled doses in the last 60 days are biologically confirmed (89%); 1 were logged but show no dose signature. Dose signature: resting HR +7 bpm, HRV −6 ms.
Trajectory is stable relative to similar patients; keep the current content.
- 🍽Keep meals regular; three to four moderate portions spaced through the day
- 🍽Include a cooked vegetable portion with each main meal
- ✓Log the daily check-in; one line is enough
- ✓Keep the current walking rhythm
- 💊Take the scheduled dose as agreed with your care team
- 💊No additional supplements this week
Adherence is not the problem.
sleep quality falling under 35 while GI rises
P-01479 is on day 114 of NBL-101 (EC-02, baseline S03): response favorable, tolerance favorable, GI deteriorating. Over 14 days response moved +1 and GI +5; discontinuation risk is 27%. The state is in the restoration basin, heading towards failing, after diverging from the model on day 17.
Butyrate capacity 60/100, diversity 3.5, rapid metabolizer. Pushing it down: Escherichia coli 9.78% (LPS load) (-25.8), Rapid metabolizer (-12.7), Poor-sleep week (-3). Pulling it up: Butyrate producers intact (+11.9).
No action has been tried yet.
No action is indicated now; the trajectory is stable relative to similar patients.
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and events- Day 0 NBL-101 started — Baseline state S03
- Day 17 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 17.
- GI instability+5
- Inflammatory activity+4
- Toxicity+4
- Treatment adherence+3
What helped?
No interventions yet.
Daily trackers
Asset settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Heading towards failing · 74 from the failing basin, 19 from restoration.
- No untried action with strong evidence. Compose one from primitives.
- Nothing clearly counter-productive in the record.
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Histamine load-1.6no signal · 31%
- Insoluble fibre+1.4no signal · 31%
- Dietary fat load-1no signal · 23%
- Simple carbohydrates+0.9no signal · 16%
- Alcohol+0.9no signal · 22%
- Spicy / capsaicin-0.6no signal · 15%
DeepGene damage signature
The metagenomic + host-DNA read-out that initializes this patient's biology and, on retest, measures whether the steering worked.
- 3 opportunists above range: Escherichia coli, Enterococcus faecium, Clostridioides difficile
- 2 keystone species absent
- 3 resistance genes
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
- Drug metabolism and exposure ↑35
- DNADPYD *2A → slower clearance
- Mucosal barrier integrity ↓30
- MicrobiomeAkkermansia low → thinner mucus layer
- Butyrate / short-chain fatty acid production ↓25
- MicrobiomeF. prausnitzii depleted
- Autonomic recovery ↓25
- WearableResting HR 79 bpm
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Rapid metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
- HRV
- 64 ms
- Sleep
- 6.3 h
- Steps
- 9,063
- Resting HR
- 76 bpm
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
- Log the daily check-in; one line is enough
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01855 | 46% | S18 | GI-04 | improved | 76 |
| P-01664 | 45% | S07 | CR-01 | improved | 85 |
| P-01711 | 43% | S03 | ME-01 | improved | 82 |
| P-01626 | 41% | S04 | GI-04 | improved | 77 |
| P-01896 | 41% | S06 | CR-01 | improved | 73 |
| P-01489 | 38% | S05 | BR-03 | improved | 83 |
| P-01428 | 37% | S18 | DT-01 | improved | 82 |
| P-01766 | 37% | S01 | BR-03 | improved | 83 |
| P-01528 | 36% | S20 | DT-01 | improved | 89 |
| P-01642 | 34% | S07 | ME-01 | improved | 59 |
| P-01342 | 33% | S13 | DT-01 | improved | 59 |
| P-01638 | 33% | S04 | GI-04 | improved | 83 |