Patient P-01625
Therapy response 85 at the day-84 endpoint (observed).
Responding: response probability 80%, therapy response 78 today; biology is not blocking the drug.
No side effect starting: gi toxicity 20, systemic toxicity 13, no drift from the model.
8 of 8 scheduled doses in the last 60 days are biologically confirmed (100%). Dose signature: resting HR +5 bpm, HRV −9 ms.
Trajectory is stable relative to similar patients; keep the current content.
- 🍽Keep meals regular; three to four moderate portions spaced through the day
- 🍽Include a cooked vegetable portion with each main meal
- ✓Log the daily check-in; one line is enough
- ✓Keep the current walking rhythm
- 💊Take the scheduled dose as agreed with your care team
- 💊No additional supplements this week
Adherence is not the problem.
sleep quality falling under 35 while GI rises
P-01625 is on day 119 of NBL-101 (SR, baseline S09): response declining, tolerance improving, GI favorable. Over 14 days response moved -6 and GI -2; discontinuation risk is 11%. The state is in the restoration basin, heading towards restoration.
Biology sets the gain: FUT2 non-secretor, Low microbial diversity; butyrate capacity 50/100, diversity 2.8. Pushing it down: 3 keystone species absent (-21.6), FUT2 non-secretor (-17.5), Clostridioides difficile 1.813% (LPS load) (-16.9). Pulling it up: Butyrate producers intact (+12.3). From the daily log: alcohol +2.9 GI next day, histamine +2.3 GI next day, fibre -1.8 GI next day, simple carbs +1.7 GI next day.
No action has been tried yet.
No action is indicated now; the trajectory is stable relative to similar patients.
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and events- Day 0 NBL-101 started — Baseline state S09
What changed?
Trajectory is tracking the baseline prediction.
- Inflammatory activity-6
- Toxicity-5
- Treatment adherence+4
- Nutritional resilience-3
- GI instability-2
What helped?
No interventions yet.
Daily trackers
Asset settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Heading towards restoration · 85 from the failing basin, 2 from restoration.
- No untried action with strong evidence. Compose one from primitives.
- More fibreGI -1.8 next day on high-intake days · n 17
- Keep alcohol lowGI +2.9 next day on high-intake days · n 21
- Keep histamine lowGI +2.3 next day on high-intake days · n 14
- Keep simple carbs lowGI +1.7 next day on high-intake days · n 20
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Alcohol+2.9detractor · 95%
- Histamine load+2.3detractor · 79%
- Insoluble fibre-1.8supporter · 61%
- Simple carbohydrates+1.7detractor · 68%
- Dietary fat load-1.3no signal · 32%
- Spicy / capsaicin-0.6no signal · 19%
DeepGene damage signature
The metagenomic + host-DNA read-out that initializes this patient's biology and, on retest, measures whether the steering worked.
- 1 opportunist above range: Clostridioides difficile
- 3 keystone species absent
- Shannon 2.56 (expected ≥ 3)
- 8 resistance genes
- Tissue recycling index 42
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
- Mucosal barrier integrity ↓30
- DNAFUT2 non-secretor lowers mucosal fucosylation
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Intermediate metabolizerExpected exposure
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
- HRV
- 62 ms
- Sleep
- 8.0 h
- Steps
- 6,715
- Resting HR
- 59 bpm
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Keep fibre steady; no new sources this week
- Avoid known triggers for now: fried or oily food, dairy, alcohol
- Log the daily check-in; one line is enough
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01428 | 50% | S18 | DT-01 | improved | 82 |
| P-01489 | 49% | S05 | BR-03 | improved | 83 |
| P-01638 | 47% | S04 | GI-04 | improved | 83 |
| P-01626 | 46% | S04 | GI-04 | improved | 77 |
| P-01664 | 44% | S07 | CR-01 | improved | 85 |
| P-01766 | 44% | S01 | BR-03 | improved | 83 |
| P-01855 | 42% | S18 | GI-04 | improved | 76 |
| P-01528 | 41% | S20 | DT-01 | improved | 89 |
| P-01896 | 38% | S06 | CR-01 | improved | 73 |
| P-01711 | 35% | S03 | ME-01 | improved | 82 |
| P-01522 | 32% | S05 | HY-01 | improved | 56 |
| P-01642 | 32% | S07 | ME-01 | improved | 59 |