Patient P-01627
Synthetic patientNBL-101 · Day 114 · 35–44 · M · baseline S14Steering view · 3DOpen companion preview
Therapy response
Improving
Tolerance
Deteriorating
GI state
Improving
Inflammatory state
Improving
Nutritional resilience
Improving
Discontinuation risk
60%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 NBL-101 started — Baseline state S14
- Day 48 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 56 GI-04 recommended — GI Support Protocol GI-04
- Day 57 Patient accepted — Started GI-04 in the companion
- Day 65 GI symptom burden −30% vs expected — GI Support Protocol GI-04
- Day 71 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 48.
Primary contributors, last 14 days
- GI instability-21
- Nutritional resilience+19
- Inflammatory activity-9
- Toxicity+9
- Treatment adherence+7
What helped?
- GI Support Protocol GI-04Day 56Result: symptom burden −30%
LIFE OS recommendation
Dietary Support Protocol NP-02
54%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 66% showed improvement
- median effect visible after 10 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
GI burden
Companion46.2/100
stable · -1.5 vs previous 14 d
Toxicity
Blood46.6/100
worsening · +2.3 vs previous 14 d
Sleep quality
Wearable14.4/100
worsening · -2.7 vs previous 14 d
Energy level
Daily log2.9/10
worsening · -0.3 vs previous 14 d
Stress level
Daily log6.2/10
stable · +0.1 vs previous 14 d
Steps
Wearable6,354
stable · +85 vs previous 14 d
Adherence
Companion58.4 %
stable · +1.8 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards restoration · 40 from the failing basin, 48 from restoration.
Would help
Would not help
- Keep fat lowGI +5.3 next day on high-intake days · n 20
- Keep histamine lowGI +4 next day on high-intake days · n 19
- Keep simple carbs lowGI +3.4 next day on high-intake days · n 19
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Dietary fat load+5.3detractor · 95%
- Histamine load+4detractor · 95%
- Simple carbohydrates+3.4detractor · 81%
- Insoluble fibre+1.4no signal · 30%
- Spicy / capsaicin+0.7no signal · 16%
- Alcohol+0.4no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Inflammatory signalling ↓85
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 53
- WearableHRV 28 ms, trending down
- Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 46 and rising
- WearableSleep 5.7 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 39/100
- MicrobiomeF. prausnitzii depleted
- Drug metabolism and exposure ↑20
- BloodToxicity index 47
- Autonomic recovery ↓20
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Rapid metabolizerExpected exposure
Microbiome
Shannon diversity 2.7 · butyrate capacity 39/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 31 ms
- Sleep
- 5.9 h
- Steps
- 5,085
- Resting HR
- 74 bpm
Daily log: GI score 46, nutritional resilience 51, adherence 58.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01706 | 62% | S14 | GI-04 | improved | 55 |
| P-01624 | 58% | S14 | GI-04 | improved | 52 |
| P-01438 | 57% | S14 | GI-04 | improved | 56 |
| P-01879 | 57% | S14 | SC-12 | improved | 51 |
| P-01556 | 54% | S14 | GI-04 | improved | 44 |
| P-01323 | 52% | S14 | GI-04 | improved | 50 |
| P-01365 | 51% | S14 | SC-12 | improved | 49 |
| P-01400 | 51% | S17 | GI-04 | improved | 51 |
| P-01393 | 50% | S14 | GI-04 | improved | 53 |
| P-01473 | 50% | S14 | GI-04 | improved | 51 |
| P-01543 | 50% | S14 | GI-04 | improved | 54 |
| P-01573 | 50% | S14 | GI-04 | improved | 49 |