Patient P-01844
Therapy response 81 at the day-84 endpoint (observed).
Responding: response probability 80%, therapy response 79 today; biology is not blocking the drug.
No side effect starting: gi toxicity 8, systemic toxicity 14, no drift from the model.
8 of 8 scheduled doses in the last 60 days are biologically confirmed (100%). Dose signature: resting HR +3 bpm, HRV −8 ms.
Trajectory is stable relative to similar patients; keep the current content.
- 🍽Keep meals regular; three to four moderate portions spaced through the day
- 🍽Include a cooked vegetable portion with each main meal
- ✓Log the daily check-in; one line is enough
- ✓A 15-minute walk after lunch
- 💊Take the scheduled dose as agreed with your care team
- 💊No additional supplements this week
Adherence is not the problem.
sleep quality falling under 35 while GI rises
P-01844 is on day 112 of NBL-101 (SR, baseline S04): response favorable, tolerance favorable, GI favorable. Over 14 days response moved -1 and GI -4; discontinuation risk is 6%. The state is in the restoration basin, heading towards restoration.
Biology sets the gain: Low microbial diversity; butyrate capacity 69/100, diversity 2.9. Pushing it down: Escherichia coli 20.459% (LPS load) (-35), 4 keystone species absent (-20.6), Alcohol (-17.8). Pulling it up: Butyrate producers intact (+11.7). From the daily log: alcohol +5.9 GI next day, simple carbs +3 GI next day.
No action has been tried yet.
No action is indicated now; the trajectory is stable relative to similar patients.
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and events- Day 0 NBL-101 started — Baseline state S04
What changed?
Trajectory is tracking the baseline prediction.
- Inflammatory activity-8
- GI instability-4
- Toxicity-3
- Nutritional resilience+2
What helped?
No interventions yet.
Daily trackers
Asset settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Heading towards restoration · 96 from the failing basin, 12 from restoration.
- Butyrate producers intacthidden · steering +11.7
- Escherichia coli 20.459% (LPS load)hidden · steering -35
- 4 keystone species absenthidden · steering -20.6
- Alcoholperturbation · steering -17.8
- Tissue recycling 45/100hidden · steering -13.2
- Alcoholdetractor · GI +5.9 next day
- Simple carbohydratesdetractor · GI +3 next day
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Alcohol+5.9detractor · 95%
- Simple carbohydrates+3detractor · 79%
- Spicy / capsaicin-2no signal · 38%
- Insoluble fibre-0.9no signal · 17%
- Dietary fat load+0.5no signal · 15%
- Histamine load-0.1no signal · 15%
DeepGene damage signature
The metagenomic + host-DNA read-out that initializes this patient's biology and, on retest, measures whether the steering worked.
- 4 opportunists above range: Escherichia coli, Klebsiella pneumoniae, Enterococcus faecium
- 4 keystone species absent
- Shannon 2.37 (expected ≥ 3)
- 7 resistance genes
- Host DNA fragmentation atypical
- Tissue recycling index 45
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
- Drug metabolism and exposure ↑35
- DNADPYD *2A → slower clearance
- Butyrate / short-chain fatty acid production ↓25
- MicrobiomeF. prausnitzii depleted
- Inflammatory signalling ↓20
- MicrobiomeBacteroides fragilis expansion
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Normal metabolizerExpected exposure
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
- HRV
- 53 ms
- Sleep
- 6.9 h
- Steps
- 4,064
- Resting HR
- 58 bpm
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
- Log the daily check-in; one line is enough
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01481 | 36% | S15 | AD-05 | no change | 67 |
| P-01468 | 27% | S03 | AD-05 | no change | 50 |
| P-01764 | 53% | S15 | BR-03 | no change | 85 |
| P-01489 | 48% | S05 | BR-03 | improved | 83 |
| P-01411 | 46% | S13 | BR-03 | no change | 76 |
| P-01766 | 44% | S01 | BR-03 | improved | 83 |
| P-01896 | 43% | S06 | CR-01 | improved | 73 |
| P-01664 | 40% | S07 | CR-01 | improved | 85 |
| P-01428 | 48% | S18 | DT-01 | improved | 82 |
| P-01472 | 46% | S20 | DT-01 | no change | 82 |
| P-01528 | 35% | S20 | DT-01 | improved | 89 |
| P-01342 | 30% | S13 | DT-01 | improved | 59 |