Emergent Cluster EC-03NEW
28 patients
Early response followed by GI deterioration and treatment discontinuation.
Emerges around
Day 48
Detectable by LIFE OS
Day 30
Median clinical recognition
Day 77
Potential lead time
47 days
Average trajectory of the cluster
mean of 28 trajectories · dashed = model expectation at baselinesolid = observed · dashed = predicted
Shared signals
- baseline state S14
- inflammatory profile (IL6 variant, low HRV)
- GI instability from day ~30
- nutritional decline
- low Akkermansia / butyrate capacity
- prior intervention pattern
- Mean response
- 49
- Mean GI score
- 57
- Discontinuation risk
- 75%
Potential action
GI-04 appears associated with improved persistence among similar patients (+17% persistence, −31% symptom burden in synthetic history).
Members
P-03003 · 53P-03030 · 43P-03037 · 43P-03049 · 49P-03070 · 51P-03081 · 53P-03090 · 48P-03103 · 63P-03110 · 52P-03123 · 50P-03145 · 51P-03146 · 53P-03159 · 37P-03226 · 43P-03251 · 54P-03279 · 57P-03289 · 54P-03293 · 41P-03300 · 46P-03323 · 48P-03332 · 54P-03341 · 49P-03345 · 56P-03365 · 46P-03390 · 41P-03413 · 48P-03430 · 45P-03460 · 46