Patient P-03279
Therapy response
Declining
Tolerance
Deteriorating
GI state
Stable
Inflammatory state
Stable
Nutritional resilience
Stable
Discontinuation risk
54%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S14
- Day 58 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 61 GI-04 recommended — GI Support Protocol GI-04
- Day 62 Patient accepted — Started GI-04 in the companion
- Day 70 GI symptom burden −34% vs expected — GI Support Protocol GI-04
- Day 76 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 58.
Primary contributors, last 14 days
- Treatment adherence-25
- Toxicity+9
- Inflammatory activity+2
What helped?
- GI Support Protocol GI-04Day 61Result: symptom burden −34%
LIFE OS recommendation
Dosing / Timing Recommendation DT-01
62%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 90% showed improvement
- median effect visible after 5 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Inflammatory signalling ↑45
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 42
- Autonomic recovery ↑45
- WearableResting HR 80 bpm
- WearableShort sleep window
- Mucosal barrier integrity ↓40
- DNAFUT2 non-secretor lowers mucosal fucosylation
- WearableSleep 5.7 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓25
- MicrobiomeF. prausnitzii depleted
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 1.9 · butyrate capacity 46/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 60 ms
- Sleep
- 6.5 h
- Steps
- 4,916
- Resting HR
- 77 bpm
Daily log: GI score 42, nutritional resilience 53, adherence 62.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03289 | 46% | S03 | SC-12 | improved | 54 |
| P-03046 | 39% | S20 | GI-04 | no change | 53 |
| P-03123 | 39% | S14 | GI-04 | improved | 50 |
| P-03146 | 38% | S14 | GI-04 | improved | 53 |
| P-03103 | 37% | S14 | GI-04 | improved | 63 |
| P-03110 | 37% | S15 | GI-04 | improved | 52 |
| P-03465 | 37% | S17 | CR-01 | improved | 65 |
| P-03070 | 36% | S14 | GI-04 | improved | 51 |
| P-03357 | 36% | S02 | CR-01 | improved | 50 |
| P-03201 | 35% | S15 | GI-04 | improved | 68 |
| P-03300 | 35% | S14 | GI-04 | improved | 46 |
| P-03365 | 33% | S14 | NP-02 | improved | 46 |