Patient P-03332
Therapy response
Declining
Tolerance
Stable
GI state
Unstable
Inflammatory state
Unstable
Nutritional resilience
Unstable
Discontinuation risk
96%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S14
- Day 39 NP-02 recommended — Dietary Support Protocol NP-02
- Day 40 Patient accepted — Started NP-02 in the companion
- Day 50 No meaningful change — Dietary Support Protocol NP-02
- Day 60 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 76 ME-01 recommended — Monitoring Escalation ME-01
- Day 77 Patient accepted — Started ME-01 in the companion
- Day 80 Deterioration detected before clinical escalation — Monitoring Escalation ME-01
What changed?
Trajectory began diverging from predicted response on Day 60.
Primary contributors, last 14 days
- Treatment adherence-23
- GI instability+10
- Inflammatory activity+9
- Nutritional resilience-8
- Toxicity-2
What helped?
- Dietary Support Protocol NP-02Day 39Result: no meaningful change
- Monitoring Escalation ME-01Day 76Result: deterioration detected before clinical escalation
LIFE OS recommendation
GI Support Protocol GI-04
91%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 81% showed improvement
- median effect visible after 8 days
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 77 and rising
- WearableSleep 6.1 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 38/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑65
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 72
- WearableHRV 25 ms, trending down
- Autonomic recovery ↓65
- WearableResting HR 86 bpm
- Wearable3,988 steps/day
- WearableShort sleep window
- Drug metabolism and exposure ↑20
- BloodToxicity index 52
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Intermediate metabolizerExpected exposure
Microbiome
Shannon diversity 3 · butyrate capacity 38/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 27 ms
- Sleep
- 6.0 h
- Steps
- 3,268
- Resting HR
- 87 bpm
Daily log: GI score 77, nutritional resilience 24, adherence 47.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03341 | 37% | S14 | NP-02 | improved | 49 |
| P-03251 | 35% | S14 | SC-12 | improved | 54 |
| P-03280 | 35% | S13 | — | — | 57 |
| P-03444 | 35% | S17 | — | — | 62 |
| P-03049 | 34% | S14 | GI-04 | improved | 49 |
| P-03293 | 34% | S14 | GI-04 | no change | 41 |
| P-03352 | 34% | S19 | — | — | 59 |
| P-03099 | 33% | S17 | CR-01 | improved | 55 |
| P-03037 | 32% | S14 | NP-02 | improved | 43 |
| P-03080 | 32% | S09 | — | — | 62 |
| P-03164 | 32% | S11 | — | — | 58 |
| P-03183 | 32% | S03 | — | — | 54 |