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Patient P-03151

Synthetic patientONX-7 · Day 139 · 55–64 · F · baseline S18Steering view · 3DOpen companion preview
Therapy response
Stable
Tolerance
Stable
GI state
Improving
Inflammatory state
Stable
Nutritional resilience
Unstable
Discontinuation risk
55%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events
solid = observed · dashed = predicted
  1. Day 0 ONX-7 started — Baseline state S18
  2. Day 96 Trajectory diverged from prediction — Observed response fell below the model's expected path.

What changed?

Trajectory began diverging from predicted response on Day 96.

Primary contributors, last 14 days
  • GI instability-18
  • Treatment adherence-16
  • Nutritional resilience+9
  • Inflammatory activity-3
  • Toxicity+2

What helped?

No interventions yet.

    LIFE OS recommendation
    GI Support Protocol GI-04
    62%
    probability of meaningful tolerance improvement
    • 284 similar trajectories
    • 83% showed improvement
    • median effect visible after 8 days
    View similar patientsSimulateAdd to intervention cohortAll evidence

    Daily trackers

    Molecule settings

    The trackers this program marks as important, last 14 days vs the 14 before.

    Energy level
    Daily log
    2.3/10
    improving · +1.0 vs previous 14 d
    Stress level
    Daily log
    6.8/10
    improving · -0.8 vs previous 14 d
    Pessimism score
    Daily log
    5.6/10
    improving · -0.4 vs previous 14 d
    Sleep quality
    Wearable
    31.2/100
    improving · +11.4 vs previous 14 d
    Libido
    Daily log
    2.8/10
    improving · +0.6 vs previous 14 d
    HRV
    Wearable
    38.7 ms
    improving · +5.1 vs previous 14 d
    Toxicity
    Blood
    50.8/100
    stable · +1.1 vs previous 14 d
    This trajectory is doing well — what to keep, what to watch
    Steering view →

    Heading towards restoration · 33 from the failing basin, 56 from restoration.

    Good elements to keep
    • Protein (supports)
      perturbation · steering +10.1
    • Protein
      supporter · GI -5.7 next day
    Main detractors to watch
    • Low butyrate capacity
      hidden · steering -17.5
    • Dietary fat load
      perturbation · steering -9.1
    • Lactose
      perturbation · steering -8.2
    • Bacteroides fragilis elevated
      hidden · steering -7.4
    • Dietary fat load
      detractor · GI +4.5 next day
    • Lactose
      detractor · GI +4.3 next day
    State influencers · digestive

    Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

    • Protein
      -5.7supporter · 95%
    • Dietary fat load
      +4.5detractor · 95%
    • Lactose
      +4.3detractor · 95%
    • Alcohol
      -1.7no signal · 36%
    • Caffeine
      -0.9no signal · 17%
    • Histamine load
      -0.4no signal · 15%

    Biological layers

    Which pathways look influenced, and by which layer of this person's biology.

    Pathways under pressure
    • Butyrate / short-chain fatty acid production ↓80
      • MicrobiomeButyrate capacity 34/100
      • MicrobiomeF. prausnitzii depleted
      • Daily logFibre intake low in recent food logs
    • Mucosal barrier integrity ↓60
      • MicrobiomeAkkermansia low → thinner mucus layer
      • Daily logGI symptom score 53 and rising
      • WearableSleep 5.9 h, below personal baseline
    • Drug metabolism and exposure ↑55
      • DNADPYD *2A → slower clearance
      • BloodToxicity index 51
    • Inflammatory signalling ↓45
      • MicrobiomeBacteroides fragilis expansion
      • BloodInflammatory load index 55
    • Autonomic recovery ↑20
      • WearableShort sleep window
    DNA
    Fictional pharmacogenomic panel
    • DPYD *2A heterozygous
      Slower drug clearance
    • CYP2D6 Normal metabolizer
      Expected exposure
    Microbiome
    Shannon diversity 3.2 · butyrate capacity 34/100
    • Akkermansia muciniphilaLow
    • Faecalibacterium prausnitziiLow
    • Bacteroides fragilisHigh
    • Bifidobacterium longumLow
    • EnterobacteriaceaeNormal
    Wearable, last 14 days
    daily evolution fed into the runtime
    HRV
    40 ms
    Sleep
    5.3 h
    Steps
    7,364
    Resting HR
    71 bpm
    Daily log: GI score 53, nutritional resilience 39, adherence 61.

    What this patient sees in NostraAI

    The content that steers the trajectory: what to eat, what to do, what to take.

    Open companion preview
    What to eat
    • Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
    • Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
    • Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
    • Avoid known triggers for now: fried or oily food, dairy, alcohol
    What to do
    • Track each bowel movement today: time, stool form, urgency, overnight waking
    • Keep the current walking rhythm
    • Protect a 7.5-hour sleep window; screens off 30 minutes before
    • Keep hydration steady: small amounts through the day rather than large volumes at once
    What to take
    • Take the scheduled dose as agreed with your care team
    • Electrolyte solution, one sachet after any loose stool
    • Fictional demo item: oral nutrition supplement with lunch

    284 biologically similar trajectories

    Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

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    P-0310520%S12AD-05no change60
    P-0311120%S07AD-05no change48
    P-0320420%S16AD-05improved48
    P-0335120%S07AD-05no change51
    P-0348220%S05AD-05no change67
    P-0303419%S14AD-05no change30
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    P-0312918%S18AD-05no change32
    P-0318718%S12AD-05no change80
    P-0338018%S16AD-05improved34
    P-0342418%S12AD-05improved41
    P-0344118%S19AD-05improved37