Patient P-03201
Therapy response
Improving
Tolerance
Deteriorating
GI state
Stable
Inflammatory state
Deteriorating
Nutritional resilience
Declining
Discontinuation risk
46%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S15
- Day 102 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 102 GI-04 recommended — GI Support Protocol GI-04
- Day 103 Patient accepted — Started GI-04 in the companion
- Day 111 GI symptom burden −12% vs expected — GI Support Protocol GI-04
- Day 117 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 102.
Primary contributors, last 14 days
- Treatment adherence-13
- Toxicity+11
- Inflammatory activity+8
- Nutritional resilience-6
What helped?
- GI Support Protocol GI-04Day 102Result: symptom burden −12%
LIFE OS recommendation
Dosing / Timing Recommendation DT-01
62%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 82% showed improvement
- median effect visible after 5 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log3.6/10
stable · -0.1 vs previous 14 d
Stress level
Daily log5.1/10
stable · +0.2 vs previous 14 d
Pessimism score
Daily log3.6/10
stable · +0.0 vs previous 14 d
Sleep quality
Wearable27.4/100
worsening · -2.2 vs previous 14 d
Libido
Daily log3.5/10
worsening · -0.4 vs previous 14 d
HRV
Wearable52.8 ms
stable · -1.5 vs previous 14 d
Toxicity
Blood35.9/100
worsening · +2.9 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards restoration · 49 from the failing basin, 47 from restoration.
Would help
- DT-01 Dosing / Timing Recommendation82% improved among 11 similar · onset 5 d · confidence 61%
- NP-02 Dietary Support Protocol57% improved among 14 similar · onset 10 d · confidence 61%
- HY-01 Hydration Protocol57% improved among 7 similar · onset 4 d · confidence 61%
- More proteinGI -5.9 next day on high-intake days · n 13
Would not help
- AD-05 Adherence Supportonly 25% improved among 8 similar
- Keep histamine lowGI +6.4 next day on high-intake days · n 18
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Histamine load+6.4detractor · 95%
- Protein-5.9supporter · 95%
- Caffeine+1.5no signal · 28%
- Alcohol+1.4no signal · 25%
- Dietary fat load-0.6no signal · 15%
- Lactose-0.6no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 51 and rising
- WearableSleep 5.9 h, below personal baseline
- Butyrate / short-chain fatty acid production ↓45
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↑40
- Wearable2,631 steps/day
- WearableShort sleep window
- Drug metabolism and exposure ↑35
- DNADPYD *2A → slower clearance
- Inflammatory signalling ↑25
- BloodInflammatory load index 54
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- DPYD *2A heterozygousSlower drug clearance
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 2.9 · butyrate capacity 45/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 50 ms
- Sleep
- 6.3 h
- Steps
- 2,742
- Resting HR
- 70 bpm
Daily log: GI score 51, nutritional resilience 42, adherence 67.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03465 | 46% | S17 | CR-01 | improved | 65 |
| P-03166 | 44% | S20 | CR-01 | improved | 62 |
| P-03451 | 43% | S08 | — | — | 62 |
| P-03271 | 42% | S19 | — | — | 66 |
| P-03046 | 41% | S20 | GI-04 | no change | 53 |
| P-03382 | 41% | S01 | GI-04 | improved | 56 |
| P-03004 | 40% | S03 | — | — | 56 |
| P-03146 | 39% | S14 | GI-04 | improved | 53 |
| P-03225 | 39% | S19 | GI-04 | improved | 50 |
| P-03260 | 39% | S19 | — | — | 54 |
| P-03267 | 39% | S05 | — | — | 62 |
| P-03280 | 38% | S13 | — | — | 57 |