Patient P-03277

Synthetic patientONX-7 · Day 145 · 55–64 · F · baseline S14Open companion preview

Therapy response

Unstable

Tolerance

Favorable

GI state

Deteriorating

Inflammatory state

Deteriorating

Nutritional resilience

Declining

Discontinuation risk

54%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 ONX-7 started — Baseline state S14
Day 90 BR-03 recommended — Behavioural Recommendation BR-03
Day 91 Patient accepted — Started BR-03 in the companion
Day 98 GI symptom burden −12% vs expected — Behavioural Recommendation BR-03
Day 104 Tolerance state changed — Unstable → Improving
Day 109 Trajectory diverged from prediction — Observed response fell below the model's expected path.

What changed?

Trajectory began diverging from predicted response on Day 109.

Primary contributors, last 14 days

GI instability+22
Nutritional resilience-14
Inflammatory activity+13
Treatment adherence+12

What helped?

Behavioural Recommendation BR-03Day 90
Result: symptom burden −12%

LIFE OS recommendation

Monitoring Escalation ME-01

79%

probability of meaningful tolerance improvement

284 similar trajectories
100% showed improvement
median effect visible after 3 days

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Autonomic recovery ↓40
- Wearable3,938 steps/day
- WearableShort sleep window
Inflammatory signalling ↑25
- DNAIL6 -174 variant raises baseline inflammatory tone

DNA

Fictional pharmacogenomic panel

IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Normal metabolizer
Expected exposure
MTHFR C677T
Reduced folate turnover

Microbiome

Shannon diversity 3.2 · butyrate capacity 73/100

Akkermansia muciniphilaNormal
Faecalibacterium prausnitziiNormal
Bacteroides fragilisNormal
Bifidobacterium longumNormal
EnterobacteriaceaeNormal

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 46 ms
Sleep: 6.4 h
Steps: 4,344
Resting HR: 59 bpm

Daily log: GI score 31, nutritional resilience 60, adherence 91.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Keep meals regular; three to four moderate portions spaced through the day
Include a cooked vegetable portion with each main meal
Keep fibre steady; no new sources this week
Avoid known triggers for now: fried or oily food, dairy, alcohol

What to do

Log the daily check-in; one line is enough
A 15-minute walk after lunch
Protect a 7.5-hour sleep window; screens off 30 minutes before
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the scheduled dose as agreed with your care team
No additional supplements this week
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-03424	46%	S12	AD-05	improved	41
P-03204	43%	S16	AD-05	improved	48
P-03369	42%	S18	AD-05	no change	37
P-03380	42%	S16	AD-05	improved	34
P-03034	41%	S14	AD-05	no change	30
P-03129	40%	S18	AD-05	no change	32
P-03111	39%	S07	AD-05	no change	48
P-03122	38%	S13	AD-05	no change	40
P-03158	37%	S17	AD-05	no change	37
P-03105	34%	S12	AD-05	no change	60
P-03104	33%	S14	AD-05	no change	27
P-03351	33%	S07	AD-05	no change	51