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Patient P-03384

Synthetic patientONX-7 · Day 144 · 45–54 · M · baseline S01Steering view · 3DOpen companion preview
Therapy response
Stable
Tolerance
Improving
GI state
Unstable
Inflammatory state
Stable
Nutritional resilience
Stable
Discontinuation risk
69%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events
solid = observed · dashed = predicted
  1. Day 0 ONX-7 started — Baseline state S01
  2. Day 100 Trajectory diverged from prediction — Observed response fell below the model's expected path.

What changed?

Trajectory began diverging from predicted response on Day 100.

Primary contributors, last 14 days
  • Toxicity-15
  • GI instability+12
  • Nutritional resilience+3

What helped?

No interventions yet.

    LIFE OS recommendation
    GI Support Protocol GI-04
    70%
    probability of meaningful tolerance improvement
    • 284 similar trajectories
    • 83% showed improvement
    • median effect visible after 8 days
    View similar patientsSimulateAdd to intervention cohortAll evidence

    Daily trackers

    Molecule settings

    The trackers this program marks as important, last 14 days vs the 14 before.

    Energy level
    Daily log
    3.4/10
    stable · +0.0 vs previous 14 d
    Stress level
    Daily log
    6.6/10
    improving · -0.4 vs previous 14 d
    Pessimism score
    Daily log
    5.3/10
    worsening · +0.3 vs previous 14 d
    Sleep quality
    Wearable
    23.5/100
    worsening · -2.1 vs previous 14 d
    Libido
    Daily log
    2.7/10
    improving · +0.3 vs previous 14 d
    HRV
    Wearable
    33 ms
    stable · +0.8 vs previous 14 d
    Toxicity
    Blood
    32.5/100
    improving · -10.1 vs previous 14 d
    This trajectory is decaying — what would help, what would not
    Steering view →

    Heading towards failing · 34 from the failing basin, 63 from restoration.

    Would help
    • GI-04 GI Support Protocol
      74% improved among 35 similar · onset 8 d · confidence 69%
    • ME-01 Monitoring Escalation
      100% improved among 11 similar · onset 3 d · confidence 75%
    • DT-01 Dosing / Timing Recommendation
      80% improved among 10 similar · onset 5 d · confidence 75%
    • More protein
      GI -5.4 next day on high-intake days · n 21
    Would not help
    • AD-05 Adherence Support
      only 30% improved among 10 similar
    • Keep fat low
      GI +5.7 next day on high-intake days · n 27
    • Keep caffeine low
      GI +5.7 next day on high-intake days · n 20
    • Keep histamine low
      GI +3.7 next day on high-intake days · n 27
    State influencers · digestive

    Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

    • Dietary fat load
      +5.7detractor · 95%
    • Caffeine
      +5.7detractor · 95%
    • Protein
      -5.4supporter · 95%
    • Histamine load
      +3.7detractor · 95%
    • Lactose
      +3.1detractor · 81%
    • Alcohol
      -0.5no signal · 15%

    Biological layers

    Which pathways look influenced, and by which layer of this person's biology.

    Pathways under pressure
    • Inflammatory signalling ↑60
      • MicrobiomeBacteroides fragilis expansion
      • BloodInflammatory load index 55
      • WearableHRV 33 ms, trending down
    • Butyrate / short-chain fatty acid production ↓55
      • MicrobiomeButyrate capacity 28/100
      • Daily logFibre intake low in recent food logs
    • Mucosal barrier integrity ↓50
      • DNAFUT2 non-secretor lowers mucosal fucosylation
      • Daily logGI symptom score 66 and rising
    • Autonomic recovery ↓45
      • WearableResting HR 84 bpm
      • WearableShort sleep window
    • Drug metabolism and exposure ↑40
      • DNACYP2D6 poor metabolizer → higher exposure
    DNA
    Fictional pharmacogenomic panel
    • FUT2 rs601338 AA (non-secretor)
      Reduced mucosal fucosylation
    • CYP2D6 Poor metabolizer
      Higher exposure at standard dose
    Microbiome
    Shannon diversity 2.7 · butyrate capacity 28/100
    • Akkermansia muciniphilaNormal
    • Faecalibacterium prausnitziiNormal
    • Bacteroides fragilisHigh
    • Bifidobacterium longumLow
    • EnterobacteriaceaeNormal
    Wearable, last 14 days
    daily evolution fed into the runtime
    HRV
    36 ms
    Sleep
    6.2 h
    Steps
    6,579
    Resting HR
    84 bpm
    Daily log: GI score 66, nutritional resilience 44, adherence 64.

    What this patient sees in NostraAI

    The content that steers the trajectory: what to eat, what to do, what to take.

    Open companion preview
    What to eat
    • Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
    • Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
    • Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
    • Avoid known triggers for now: fried or oily food, dairy, alcohol
    What to do
    • Track each bowel movement today: time, stool form, urgency, overnight waking
    • Keep the current walking rhythm
    • Protect a 7.5-hour sleep window; screens off 30 minutes before
    • Keep hydration steady: small amounts through the day rather than large volumes at once
    What to take
    • Take the scheduled dose as agreed with your care team
    • Electrolyte solution, one sachet after any loose stool
    • Fictional demo item: oral nutrition supplement with lunch

    284 biologically similar trajectories

    Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

    Sort by similaritySort by interventionSort by outcomeSort by stateSort by response
    PatientSimilarityBaselineInterventionOutcomeResponse today
    P-0318344%S03——54
    P-0344444%S17——62
    P-0309943%S17CR-01improved55
    P-0335243%S19——59
    P-0316642%S20CR-01improved62
    P-0326042%S19——54
    P-0326742%S05——62
    P-0306541%S16——59
    P-0315141%S18——51
    P-0328041%S13——57
    P-0304639%S20GI-04no change53
    P-0319138%S19GI-04improved51