Patient P-03405
Therapy response
Favorable
Tolerance
Deteriorating
GI state
Deteriorating
Inflammatory state
Deteriorating
Nutritional resilience
Declining
Discontinuation risk
62%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S16
What changed?
Trajectory is tracking the baseline prediction.
Primary contributors, last 14 days
- GI instability+19
- Toxicity+19
- Inflammatory activity+18
- Nutritional resilience-14
- Treatment adherence-12
What helped?
No interventions yet.
LIFE OS recommendation
GI Support Protocol GI-04
62%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 81% showed improvement
- median effect visible after 8 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log4.7/10
worsening · -0.9 vs previous 14 d
Stress level
Daily log5.8/10
worsening · +1.2 vs previous 14 d
Pessimism score
Daily log5/10
worsening · +0.6 vs previous 14 d
Sleep quality
Wearable56.3/100
worsening · -3.6 vs previous 14 d
Libido
Daily log3.1/10
worsening · -0.8 vs previous 14 d
HRV
Wearable58.1 ms
worsening · -3.4 vs previous 14 d
Toxicity
Blood33.9/100
worsening · +9.1 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 45 from the failing basin, 47 from restoration.
Would help
- GI-04 GI Support Protocol82% improved among 28 similar · onset 8 d · confidence 61%
- DT-01 Dosing / Timing Recommendation83% improved among 12 similar · onset 5 d · confidence 71%
- ME-01 Monitoring Escalation100% improved among 6 similar · onset 3 d · confidence 71%
- More proteinGI -8.2 next day on high-intake days · n 16
Would not help
- Keep fat lowGI +7.4 next day on high-intake days · n 25
- Keep lactose lowGI +6.6 next day on high-intake days · n 22
- Keep histamine lowGI +6 next day on high-intake days · n 23
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-8.2supporter · 95%
- Dietary fat load+7.4detractor · 95%
- Lactose+6.6detractor · 95%
- Histamine load+6detractor · 95%
- Alcohol+3.8detractor · 67%
- Caffeine+1.3no signal · 23%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Mucosal barrier integrity ↓80
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 53 and rising
- Inflammatory signalling ↑70
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 50
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 28/100
- Daily logFibre intake low in recent food logs
- Autonomic recovery ↑25
- WearableResting HR 74 bpm
DNA
Fictional pharmacogenomic panel
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 2.2 · butyrate capacity 28/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 54 ms
- Sleep
- 7.4 h
- Steps
- 6,555
- Resting HR
- 68 bpm
Daily log: GI score 53, nutritional resilience 45, adherence 88.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.