Patient P-03463
Therapy response
Stable
Tolerance
Deteriorating
GI state
Improving
Inflammatory state
Improving
Nutritional resilience
Improving
Discontinuation risk
47%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S11
- Day 42 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 102 GI-04 recommended — GI Support Protocol GI-04
- Day 103 Patient accepted — Started GI-04 in the companion
- Day 111 No meaningful change — GI Support Protocol GI-04
What changed?
Trajectory began diverging from predicted response on Day 42.
Primary contributors, last 14 days
- Inflammatory activity-11
- Treatment adherence-9
- GI instability-6
- Nutritional resilience+5
- Toxicity+5
What helped?
- GI Support Protocol GI-04Day 102Result: no meaningful change
LIFE OS recommendation
Supportive Compound SC-12
58%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 88% showed improvement
- median effect visible after 6 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log3.4/10
stable · -0.1 vs previous 14 d
Stress level
Daily log6.4/10
stable · -0.0 vs previous 14 d
Pessimism score
Daily log5.2/10
stable · -0.1 vs previous 14 d
Sleep quality
Wearable27.8/100
worsening · -2.6 vs previous 14 d
Libido
Daily log2.5/10
worsening · -0.3 vs previous 14 d
HRV
Wearable27 ms
stable · -1.1 vs previous 14 d
Toxicity
Blood46/100
worsening · +8.0 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards restoration · 43 from the failing basin, 45 from restoration.
Would help
- ME-01 Monitoring Escalation100% improved among 11 similar · onset 3 d · confidence 52%
- SC-12 Supportive Compound89% improved among 9 similar · onset 6 d · confidence 52%
- NP-02 Dietary Support Protocol57% improved among 14 similar · onset 10 d · confidence 52%
- More proteinGI -5.4 next day on high-intake days · n 22
Would not help
- GI-04 GI Support Protocolalready tried, no meaningful change
- AD-05 Adherence Supportonly 30% improved among 10 similar
- Keep fat lowGI +4.2 next day on high-intake days · n 20
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-5.4supporter · 95%
- Dietary fat load+4.2detractor · 95%
- Alcohol+2.1no signal · 44%
- Caffeine+1.5no signal · 32%
- Histamine load+0.7no signal · 15%
- Lactose-0.2no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 25/100
- Daily logFibre intake low in recent food logs
- Mucosal barrier integrity ↓50
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 48 and rising
- Autonomic recovery ↓45
- WearableResting HR 80 bpm
- WearableShort sleep window
- Inflammatory signalling ↓40
- BloodInflammatory load index 46
- WearableHRV 27 ms, trending down
- Drug metabolism and exposure ↑20
- BloodToxicity index 46
DNA
Fictional pharmacogenomic panel
- CYP2D6 Normal metabolizerExpected exposure
Microbiome
Shannon diversity 1.9 · butyrate capacity 25/100
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 30 ms
- Sleep
- 5.4 h
- Steps
- 3,552
- Resting HR
- 80 bpm
Daily log: GI score 48, nutritional resilience 44, adherence 70.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03021 | 52% | S15 | — | — | 57 |
| P-03031 | 48% | S16 | CR-01 | improved | 49 |
| P-03382 | 45% | S01 | GI-04 | improved | 56 |
| P-03225 | 43% | S19 | GI-04 | improved | 50 |
| P-03451 | 41% | S08 | — | — | 62 |
| P-03280 | 40% | S13 | — | — | 57 |
| P-03379 | 38% | S12 | GI-04 | improved | 51 |
| P-03004 | 37% | S03 | — | — | 56 |
| P-03166 | 37% | S20 | CR-01 | improved | 62 |
| P-03183 | 36% | S03 | — | — | 54 |
| P-03191 | 36% | S19 | GI-04 | improved | 51 |
| P-03226 | 36% | S05 | GI-04 | improved | 43 |