Patient P-02235

Synthetic patientMETA-24 · Day 132 · 25–34 · M · baseline S14Steering view · 3D Open companion preview

Therapy response

Declining

Tolerance

Deteriorating

GI state

Deteriorating

Inflammatory state

Deteriorating

Nutritional resilience

Declining

Discontinuation risk

28%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 META-24 started — Baseline state S14
Day 11 Trajectory diverged from prediction — Observed response fell below the model's expected path.
Day 22 DT-01 recommended — Dosing / Timing Recommendation DT-01
Day 23 Patient accepted — Started DT-01 in the companion
Day 28 GI symptom burden −16% vs expected — Dosing / Timing Recommendation DT-01
Day 34 Tolerance state changed — Unstable → Improving

What changed?

Trajectory began diverging from predicted response on Day 11.

Primary contributors, last 14 days

Inflammatory activity+7
Nutritional resilience-6
Toxicity+6
GI instability+4
Treatment adherence+3

What helped?

Dosing / Timing Recommendation DT-01Day 22
Result: symptom burden −16%

LIFE OS recommendation

No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

Active minutes

Wearable

64 min

worsening · -4.1 vs previous 14 d

Sleep duration

Wearable

6.7 h

stable · -0.1 vs previous 14 d

Energy level

Daily log

5.6/10

worsening · -0.4 vs previous 14 d

Steps

Wearable

6,400

stable · -285 vs previous 14 d

GI burden

Companion

20.4/100

worsening · +1.9 vs previous 14 d

Adherence

Companion

100 %

stable · -0.8 vs previous 14 d

Sleep quality

Wearable

46.9/100

stable · +1.0 vs previous 14 d

Glucose, CGM daily mean

CGM

131 mg/dL

stable · +4.3 vs previous 14 d

This trajectory is decaying — what would help, what would not

Steering view →

Heading towards failing · 69 from the failing basin, 28 from restoration.

Would help

No untried action with strong evidence. Compose one from primitives.
More protein
GI -4.3 next day on high-intake days · n 20

Would not help

Keep fat low
GI +3.9 next day on high-intake days · n 17
Keep simple carbs low
GI +2.5 next day on high-intake days · n 13
Keep ultra-processed low
GI +2.4 next day on high-intake days · n 18

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Protein
-4.3supporter · 95%
Dietary fat load
+3.9detractor · 95%
Simple carbohydrates
+2.5detractor · 95%
Ultra-processed food
+2.4detractor · 88%
Caffeine
-1.2no signal · 38%
Insoluble fibre
+0.4no signal · 15%
Alcohol
-0.3no signal · 15%
Histamine load
0no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Inflammatory signalling ↑45
- DNAIL6 -174 variant raises baseline inflammatory tone
- MicrobiomeBacteroides fragilis expansion
Butyrate / short-chain fatty acid production ↓35
- MicrobiomeButyrate capacity 30/100
Mucosal barrier integrity ↓30
- MicrobiomeAkkermansia low → thinner mucus layer

DNA

Fictional pharmacogenomic panel

IL6 -174 G/C
Higher inflammatory tone
CYP2D6 Normal metabolizer
Expected exposure
GLP1R rs6923761 A
Altered receptor sensitivity

Microbiome

Shannon diversity 2.7 · butyrate capacity 30/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiNormal
Bacteroides fragilisHigh
Bifidobacterium longumNormal
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 45 ms
Sleep: 6.8 h
Steps: 7,164
Resting HR: 62 bpm

Daily log: GI score 20, nutritional resilience 63, adherence 100.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Keep meals regular; three to four moderate portions spaced through the day
Include a cooked vegetable portion with each main meal
Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
Eat slowly and stop at comfortable fullness — smaller volume, more often

What to do

Log the daily check-in; one line is enough
Keep the current walking rhythm
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the dose at the same time relative to your evening meal
No additional supplements this week
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-02031	38%	S12	AD-05	improved	47
P-02285	38%	S14	AD-05	no change	39
P-02093	35%	S05	AD-05	no change	40
P-02267	39%	S09	BR-03	no change	45
P-02483	39%	S06	BR-03	no change	64
P-02087	38%	S01	BR-03	no change	40
P-02280	38%	S07	BR-03	no change	50
P-02522	35%	S01	BR-03	no change	40
P-02354	33%	S01	CR-01	improved	78
P-02274	53%	S15	DT-01	improved	50
P-02339	52%	S03	DT-01	improved	50
P-02455	47%	S09	DT-01	improved	50