Patient P-02321
Synthetic patientMETA-24 · Day 168 · 55–64 · F · baseline S17Steering view · 3DOpen companion preview
Therapy response
Declining
Tolerance
Improving
GI state
Improving
Inflammatory state
Improving
Nutritional resilience
Stable
Discontinuation risk
40%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 META-24 started — Baseline state S17
- Day 25 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 122 GI-04 recommended — GI Support Protocol GI-04
- Day 123 Patient accepted — Started GI-04 in the companion
- Day 131 GI symptom burden −28% vs expected — GI Support Protocol GI-04
- Day 137 Tolerance state changed — Unstable → Improving
What changed?
Trajectory began diverging from predicted response on Day 25.
Primary contributors, last 14 days
- Toxicity-9
- GI instability-8
- Inflammatory activity-5
What helped?
- GI Support Protocol GI-04Day 122Result: symptom burden −28%
LIFE OS recommendation
Dosing / Timing Recommendation DT-01
59%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 80% showed improvement
- median effect visible after 5 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Active minutes
Wearable59 min
worsening · -4.0 vs previous 14 d
Sleep duration
Wearable6.4 h
worsening · -0.4 vs previous 14 d
Energy level
Daily log3.7/10
worsening · -0.9 vs previous 14 d
Steps
Wearable6,758
worsening · -388 vs previous 14 d
GI burden
Companion39.1/100
worsening · +17.2 vs previous 14 d
Adherence
Companion73.8 %
stable · -1.8 vs previous 14 d
Sleep quality
Wearable39.3/100
worsening · -9.5 vs previous 14 d
Glucose, CGM daily mean
CGM133 mg/dL
worsening · +7.2 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards restoration · 48 from the failing basin, 39 from restoration.
Would help
- ME-01 Monitoring Escalation100% improved among 24 similar · onset 3 d · confidence 59%
- SC-12 Supportive Compound83% improved among 18 similar · onset 6 d · confidence 59%
- NP-02 Dietary Support Protocol65% improved among 20 similar · onset 10 d · confidence 59%
- More proteinGI -7.8 next day on high-intake days · n 17
Would not help
- Keep fat lowGI +6.3 next day on high-intake days · n 17
- Keep caffeine lowGI +5.4 next day on high-intake days · n 24
- Keep alcohol lowGI +5.3 next day on high-intake days · n 26
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-7.8supporter · 95%
- Dietary fat load+6.3detractor · 95%
- Caffeine+5.4detractor · 95%
- Alcohol+5.3detractor · 95%
- Insoluble fibre-1.7no signal · 31%
- Histamine load+0.7no signal · 15%
- Simple carbohydrates+0.2no signal · 15%
- Ultra-processed food-0.2no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 44/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Drug metabolism and exposure ↑60
- DNACYP2D6 poor metabolizer → higher exposure
- BloodToxicity index 45
- Inflammatory signalling ↓45
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 44
- Autonomic recovery ↑45
- WearableResting HR 76 bpm
- WearableShort sleep window
DNA
Fictional pharmacogenomic panel
- CYP2D6 Poor metabolizerHigher exposure at standard dose
Microbiome
Shannon diversity 3.2 · butyrate capacity 44/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 39 ms
- Sleep
- 5.9 h
- Steps
- 6,505
- Resting HR
- 80 bpm
Daily log: GI score 39, nutritional resilience 47, adherence 74.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
What to do
- Log the daily check-in; one line is enough
- Keep the current walking rhythm
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the dose at the same time relative to your evening meal
- No additional supplements this week
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.