Patient P-02358

Synthetic patientMETA-24 · Day 178 · 25–34 · F · baseline S18Steering view · 3D Open companion preview

Therapy response

Improving

Tolerance

Improving

GI state

Improving

Inflammatory state

Improving

Nutritional resilience

Improving

Discontinuation risk

12%

Trajectory

Baseline → today → 30-day prediction · hover a day for signals and events

solid = observed · dashed = predicted

Day 0 META-24 started — Baseline state S18
Day 34 Trajectory diverged from prediction — Observed response fell below the model's expected path.

What changed?

Trajectory began diverging from predicted response on Day 34.

Primary contributors, last 14 days

Toxicity-19
Inflammatory activity-18
GI instability-17
Nutritional resilience+10
Treatment adherence-6

What helped?

No interventions yet.

LIFE OS recommendation

No intervention is indicated right now. The trajectory is stable relative to similar patients. See what worked for similar patients.

Daily trackers

Molecule settings

The trackers this program marks as important, last 14 days vs the 14 before.

Active minutes

Wearable

96 min

improving · +10.8 vs previous 14 d

Sleep duration

Wearable

7 h

improving · +0.5 vs previous 14 d

Energy level

Daily log

5.9/10

improving · +0.9 vs previous 14 d

Steps

Wearable

11,008

improving · +1,031 vs previous 14 d

GI burden

Companion

16.2/100

improving · -9.5 vs previous 14 d

Adherence

Companion

84.9 %

stable · +2.4 vs previous 14 d

Sleep quality

Wearable

43.4/100

improving · +8.9 vs previous 14 d

Glucose, CGM daily mean

CGM

123 mg/dL

stable · -5.3 vs previous 14 d

This trajectory is doing well — what to keep, what to watch

Steering view →

Heading towards restoration · 79 from the failing basin, 13 from restoration.

Good elements to keep

Protein (supports)
perturbation · steering +10.4
Butyrate producers intact
hidden · steering +7.5
Daily walks resumed
perturbation · steering +3.3
Protein
supporter · GI -6.2 next day

Main detractors to watch

Poor metabolizer
hidden · steering -12.7
Caffeine
perturbation · steering -11.3
Bacteroides fragilis elevated
hidden · steering -7.4
Poor-sleep week
perturbation · steering -3
Caffeine
detractor · GI +6.1 next day

State influencers · digestive

Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.

Protein
-6.2supporter · 95%
Caffeine
+6.1detractor · 95%
Dietary fat load
-2.7no signal · 28%
Insoluble fibre
+2.2no signal · 46%
Simple carbohydrates
-1.3no signal · 26%
Histamine load
+0.6no signal · 15%
Ultra-processed food
+0.4no signal · 15%
Alcohol
0no signal · 15%

Biological layers

Which pathways look influenced, and by which layer of this person's biology.

Pathways under pressure

Drug metabolism and exposure ↑40
- DNACYP2D6 poor metabolizer → higher exposure
Inflammatory signalling ↓35
- MicrobiomeBacteroides fragilis expansion
- WearableHRV 31 ms, trending down
Mucosal barrier integrity ↓30
- MicrobiomeAkkermansia low → thinner mucus layer

DNA

Fictional pharmacogenomic panel

CYP2D6 Poor metabolizer
Higher exposure at standard dose
GLP1R rs6923761 A
Altered receptor sensitivity

Microbiome

Shannon diversity 3.3 · butyrate capacity 66/100

Akkermansia muciniphilaLow
Faecalibacterium prausnitziiNormal
Bacteroides fragilisHigh
Bifidobacterium longumLow
EnterobacteriaceaeHigh

Wearable, last 14 days

daily evolution fed into the runtime

HRV: 32 ms
Sleep: 6.8 h
Steps: 8,965
Resting HR: 70 bpm

Daily log: GI score 16, nutritional resilience 68, adherence 85.

What this patient sees in NostraAI

The content that steers the trajectory: what to eat, what to do, what to take.

Open companion preview

What to eat

Keep meals regular; three to four moderate portions spaced through the day
Include a cooked vegetable portion with each main meal
Keep fibre steady; no new sources this week
Eat slowly and stop at comfortable fullness — smaller volume, more often

What to do

Log the daily check-in; one line is enough
Keep the current walking rhythm
Keep the sleep window steady
Keep hydration steady: small amounts through the day rather than large volumes at once

What to take

Take the dose at the same time relative to your evening meal
No additional supplements this week
Fictional demo item: continue vitamin D as before

284 biologically similar trajectories

Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.

Patient	Similarity	Baseline	Intervention	Outcome	Response today
P-02031	31%	S12	AD-05	improved	47
P-02285	31%	S14	AD-05	no change	39
P-02483	37%	S06	BR-03	no change	64
P-02267	34%	S09	BR-03	no change	45
P-02282	31%	S01	BR-03	no change	88
P-02354	40%	S01	CR-01	improved	78
P-02518	45%	S17	DT-01	improved	68
P-02462	43%	S12	DT-01	improved	65
P-02491	43%	S09	DT-01	no change	65
P-02126	39%	S16	DT-01	improved	59
P-02330	38%	S15	DT-01	no change	57
P-02455	38%	S09	DT-01	improved	50