Patient P-02634
Metabolic response 75 at the day-84 endpoint (observed).
Responding: response probability 54%, metabolic response 62 today; biology is not blocking the drug.
Drift detected on day 71 (resting HR +4 bpm, inflammatory load +10); the side effect would have been reported on day 96 — 25 days of warning.
46 of 61 scheduled doses in the last 60 days are biologically confirmed (75%); 11 were logged but show no dose signature. Dose signature: resting HR +6 bpm, HRV −6 ms.
91% of 284 similar trajectories improved after GI-04; if this one does, discontinuation risk is expected to fall from 80% to ~50%. Keeping simple carbs low is worth 3.5 GI points a day on its own. Losing this patient costs €6k; the intervention costs €45.
- 🍽Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- 🍽Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- ✓Track each bowel movement today: time, stool form, urgency, overnight waking
- ✓A 15-minute walk after lunch
- 💊Take the dose at the same time relative to your evening meal
- 💊Electrolyte solution, one sachet after any loose stool
Partial adherence; to-dos are being skipped on symptomatic days.
GI burden above 60 for 3 days within the onset window
P-02634 is on day 105 of META-24 (EC-03, baseline S14): response favorable, tolerance deteriorating, GI stable. Over 14 days response moved -1 and GI -3; discontinuation risk is 80%. The state is between basins, heading towards restoration, after diverging from the model on day 71.
Biology sets the gain: FUT2 non-secretor, IL6 high-expression variant, Low microbial diversity, Baseline state S14, Cluster EC-03 (high response / high intolerance); butyrate capacity 45/100, diversity 2.4. Pushing it down: Escherichia coli 33.687% (LPS load) (-33.3), 6 keystone species absent (-19.6), FUT2 non-secretor (-15.9). Pulling it up: Dietary Support Protocol NP-02 (+30.8), Butyrate producers intact (+11.2). From the daily log: simple carbs +3.5 GI next day, ultra-processed +3.1 GI next day, protein -2.8 GI next day.
Past actions: NP-02 on day 48 → improved (19%); ME-01 on day 93 → improved (3%).
Next: GI-04 — 91% of 284 similar trajectories improved, 92% probability here. This would be contradicted by a further GI rise within the onset window or falling adherence.
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and events- Day 0 META-24 started — Baseline state S14
- Day 47 NP-02 recommended — Dietary Support Protocol NP-02
- Day 48 Patient accepted — Started NP-02 in the companion
- Day 58 GI symptom burden −19% vs expected — Dietary Support Protocol NP-02
- Day 64 Tolerance state changed — Unstable → Improving
- Day 71 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 92 ME-01 recommended — Monitoring Escalation ME-01
- Day 93 Patient accepted — Started ME-01 in the companion
- Day 96 Deterioration detected before clinical escalation — Monitoring Escalation ME-01
What changed?
Trajectory began diverging from predicted response on Day 71.
- Treatment adherence-16
- Toxicity+6
- GI instability-3
What helped?
- Dietary Support Protocol NP-02Day 47Result: symptom burden −19%
- Monitoring Escalation ME-01Day 92Result: deterioration detected before clinical escalation
- 284 similar trajectories
- 91% showed improvement
- median effect visible after 8 days
Daily trackers
Asset settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Heading towards restoration · 43 from the failing basin, 49 from restoration.
- GI-04 GI Support Protocol73% improved among 60 similar · onset 8 d · confidence 88%
- SC-12 Supportive Compound77% improved among 26 similar · onset 6 d · confidence 71%
- CR-01 Clinician Review100% improved among 12 similar · onset 5 d · confidence 71%
- More proteinGI -2.8 next day on high-intake days · n 21
- Keep simple carbs lowGI +3.5 next day on high-intake days · n 14
- Keep ultra-processed lowGI +3.1 next day on high-intake days · n 16
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Simple carbohydrates+3.5detractor · 95%
- Ultra-processed food+3.1detractor · 95%
- Protein-2.8supporter · 95%
- Insoluble fibre+1.8no signal · 54%
- Alcohol+0.3no signal · 15%
- Dietary fat load+0.1no signal · 15%
DeepGene damage signature
The metagenomic + host-DNA read-out that initializes this patient's biology and, on retest, measures whether the steering worked.
- 5 opportunists above range: Escherichia coli, Klebsiella pneumoniae, Enterococcus faecium
- 6 keystone species absent
- Shannon 1.58 (expected ≥ 3)
- 10 resistance genes
- Host DNA fragmentation atypical
- Tissue recycling index 61
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
- Mucosal barrier integrity ↓90
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Daily logGI symptom score 52 and rising
- WearableSleep 5.1 h, below personal baseline
- Inflammatory signalling ↓65
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 55
- WearableHRV 36 ms, trending down
- Autonomic recovery ↓65
- WearableResting HR 80 bpm
- Wearable2,171 steps/day
- WearableShort sleep window
- Butyrate / short-chain fatty acid production ↓45
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Drug metabolism and exposure ↑20
- BloodToxicity index 54
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Normal metabolizerExpected exposure
- GLP1R rs6923761 AAltered receptor sensitivity
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
- HRV
- 38 ms
- Sleep
- 5.6 h
- Steps
- 1,985
- Resting HR
- 78 bpm
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
- Take the dose at the same time relative to your evening meal
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02244 | 51% | S05 | GI-04 | improved | 61 |
| P-02505 | 48% | S14 | GI-04 | improved | 63 |
| P-02222 | 43% | S14 | GI-04 | improved | 63 |
| P-02178 | 42% | S14 | GI-04 | improved | 64 |
| P-02637 | 42% | S14 | NP-02 | improved | 65 |
| P-02282 | 39% | S14 | GI-04 | improved | 59 |
| P-02291 | 39% | S14 | GI-04 | improved | 71 |
| P-02270 | 38% | S14 | GI-04 | improved | 61 |
| P-02375 | 37% | S10 | CR-01 | improved | 68 |
| P-02472 | 37% | S14 | ME-01 | improved | 50 |
| P-02303 | 36% | S14 | NP-02 | improved | 66 |
| P-02027 | 35% | S11 | CR-01 | improved | 62 |