Patient P-01677
Therapy response 83 at the day-84 endpoint (observed).
Responding: response probability 80%, therapy response 82 today; biology is not blocking the drug.
Drift detected on day 18 (HRV −25 ms, resting HR +12 bpm, sleep −0.9 h, gi toxicity +57, inflammatory load +40); the side effect would have been reported on day 21 — 3 days of warning.
7 of 9 scheduled doses in the last 60 days are biologically confirmed (78%); 1 were logged but show no dose signature. Dose signature: resting HR +7 bpm, HRV −6 ms.
Trajectory is stable relative to similar patients; keep the current content.
- 🍽Keep meals regular; three to four moderate portions spaced through the day
- 🍽Include a cooked vegetable portion with each main meal
- ✓Log the daily check-in; one line is enough
- ✓A 15-minute walk after lunch
- 💊Take the scheduled dose as agreed with your care team
- 💊No additional supplements this week
Adherence is not the problem.
sleep quality falling under 35 while GI rises
P-01677 is on day 101 of NBL-101 (EC-02, baseline S15): response declining, tolerance deteriorating, GI deteriorating. Over 14 days response moved -5 and GI +7; discontinuation risk is 30%. The state is in the restoration basin, heading towards failing, after diverging from the model on day 18.
Butyrate capacity 64/100, diversity 3.9, intermediate metabolizer. Pushing it down: Escherichia coli 9.853% (LPS load) (-23.6), Low-HRV stretch (-2.7), Dietary drift (-2.6). Pulling it up: Butyrate producers intact (+10.8).
No action has been tried yet.
No action is indicated now; the trajectory is stable relative to similar patients.
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and events- Day 0 NBL-101 started — Baseline state S15
- Day 18 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 18.
- GI instability+7
- Inflammatory activity-4
- Toxicity+4
- Treatment adherence-2
What helped?
No interventions yet.
Daily trackers
Asset settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Heading towards failing · 80 from the failing basin, 15 from restoration.
- No untried action with strong evidence. Compose one from primitives.
- Nothing clearly counter-productive in the record.
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Spicy / capsaicin+2.2no signal · 40%
- Simple carbohydrates-2.1no signal · 39%
- Insoluble fibre-1.6no signal · 32%
- Alcohol+1.3no signal · 27%
- Dietary fat load-1.1no signal · 22%
- Histamine load+0.4no signal · 15%
DeepGene damage signature
The metagenomic + host-DNA read-out that initializes this patient's biology and, on retest, measures whether the steering worked.
- 3 opportunists above range: Escherichia coli, Klebsiella pneumoniae, Enterococcus faecium
- 2 keystone species absent
- 4 resistance genes
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
- Autonomic recovery ↓45
- WearableResting HR 76 bpm
- Wearable3,733 steps/day
- Mucosal barrier integrity ↓30
- MicrobiomeAkkermansia low → thinner mucus layer
- Butyrate / short-chain fatty acid production ↓25
- MicrobiomeF. prausnitzii depleted
- Inflammatory signalling ↓15
- WearableHRV 37 ms, trending down
- CYP2D6 Intermediate metabolizerExpected exposure
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
- HRV
- 43 ms
- Sleep
- 7.8 h
- Steps
- 4,161
- Resting HR
- 77 bpm
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
- Log the daily check-in; one line is enough
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-01481 | 32% | S15 | AD-05 | no change | 67 |
| P-01411 | 37% | S13 | BR-03 | no change | 76 |
| P-01766 | 36% | S01 | BR-03 | improved | 83 |
| P-01489 | 35% | S05 | BR-03 | improved | 83 |
| P-01764 | 35% | S15 | BR-03 | no change | 85 |
| P-01896 | 41% | S06 | CR-01 | improved | 73 |
| P-01664 | 38% | S07 | CR-01 | improved | 85 |
| P-01725 | 31% | S01 | CR-01 | improved | 62 |
| P-01428 | 34% | S18 | DT-01 | improved | 82 |
| P-01472 | 33% | S20 | DT-01 | no change | 82 |
| P-01528 | 32% | S20 | DT-01 | improved | 89 |
| P-01342 | 31% | S13 | DT-01 | improved | 59 |