Emergent Cluster EC-01NEW
45 patients
Response builds, then fades from the second month without a toxicity signal.
Emerges around
Day 75
Detectable by LIFE OS
Day 57
Median clinical recognition
Day 108
Potential lead time
51 days
Average trajectory of the cluster
mean of 45 trajectories · dashed = model expectation at baselinesolid = observed · dashed = predicted
Shared signals
- response plateau by day ~35
- no toxicity signal
- adherence drift after day ~70
- declining step count
- Mean response
- 39
- Mean GI score
- 19
- Discontinuation risk
- 20%
Potential action
AD-05 appears associated with improved persistence among similar patients (+14% persistence, −2% symptom burden in synthetic history).
Members
P-03014 · 32P-03034 · 30P-03041 · 55P-03096 · 24P-03108 · 32P-03111 · 48P-03117 · 35P-03122 · 40P-03128 · 32P-03129 · 32P-03139 · 42P-03149 · 37P-03153 · 40P-03158 · 37P-03173 · 39P-03197 · 41P-03202 · 44P-03204 · 48P-03206 · 28P-03236 · 39P-03250 · 44P-03269 · 40P-03274 · 40P-03277 · 41P-03308 · 39P-03343 · 45P-03351 · 51P-03362 · 42P-03369 · 37P-03373 · 34P-03376 · 27P-03380 · 34P-03396 · 37P-03411 · 51P-03418 · 38P-03424 · 41P-03433 · 34P-03441 · 37P-03447 · 44P-03455 · 32P-03457 · 67P-03477 · 56P-03494 · 38P-03497 · 29P-03498 · 31