Compare
| A | B | A − B | |
|---|---|---|---|
| Patients | 45 | 176 | -131 |
| Mean treatment day | 130 | 129 | +1 |
| Strong responders | 0% | 100% | -100% |
| Discontinuation risk ≥ 70% | 0% | 0% | 0% |
| At risk | 0% | 0% | 0% |
| Tolerance deteriorating | 27% | 32% | -5% |
| GI unstable | 0% | 0% | 0% |
| Response today | 41 | 81 | -40 |
| GI burden today | 17 | 16 | +1 |
| Toxicity today | 13 | 13 | 0 |
| Adherence | 85% | 92% | -7% |
| Quality of life | 58 | 77 | -19 |
| Segment | A | B | A − B |
|---|---|---|---|
| FUT2 non-secretor | 64% | 22% | +42 pp |
| IL6 high-expression variant | 56% | 21% | +35 pp |
| Poor metabolizer | 33% | 16% | +17 pp |
| Low butyrate capacity | 73% | 1% | +72 pp |
| Low microbial diversity | 87% | 6% | +81 pp |
| Baseline state S14 | 7% | 7% | 0 pp |
| Cluster EC-03 (high response / high intolerance) | 0% | 0% | 0 pp |
| Adherence < 60% | 0% | 0% | 0 pp |
EC-01 · Delayed loss of response: 45 patients, mean day 130. 27% have deteriorating tolerance, 0% unstable GI, 0% carry ≥60% discontinuation risk; mean GI 17, adherence 85%. Dominant clusters: EC-01 100%.
Shared biology: Low microbial diversity 87%, Low butyrate capacity 73%, FUT2 non-secretor 64%, IL6 high-expression variant 56%, Poor metabolizer 33%. Dietary detractors: fat in 89%, lactose in 84%, histamine in 67%.
What worked: BR-03 improved 71% of 7; what did not: AD-05 improved only 40% of 5. By biology: BR-03 works best in Low butyrate capacity (80%) and worst in Low microbial diversity (67%); AD-05 works best in Low microbial diversity (40%) and worst in IL6 high-expression variant (25%).
No learned rules apply yet; run learning after the first campaign results.
minResponseProbability 0.65: 176 patients, mean day 129. 32% have deteriorating tolerance, 0% unstable GI, 0% carry ≥60% discontinuation risk; mean GI 16, adherence 92%. Dominant clusters: SR 68%, EC-02 24%, MR 7%.
Shared biology: no dominant biology. Dietary detractors: lactose in 63%, alcohol in 37%, histamine in 27%.
No accepted actions in this cohort yet.
No learned rules apply yet; run learning after the first campaign results.