DeepGene damage signature
SyntheticSynthetic demo data2 samples: baseline day 0 · retest day 90
Damage score · retest day 90
23/100
vs baseline (day 0)
-9
7 improved · 2 worsened
synthetic signature · consistent with this patient's biology
- 3 opportunists above range: Escherichia coli, Enterococcus faecium, Streptococcus gallolyticus
- 1 keystone species absent
- 2 resistance genes
Pathogens / opportunists3/5
↑ from 2
Keystone species1/8
↓ from 2
Diversity0/2
Metabolic modules1/4
Vitamin synthesis1/7
↓ from 2
Oral translocation0/1
↓ from 1
Host DNA0/1
Tissue recycling0/1
Central mechanisms0/2
Virulence factors1/1
↓ from 2
Antibiotic resistance genes2/2
↓ from 4
Genetic predisposition2/2
Opportunists above range
Escherichia coli 6.179% AR
Enterococcus faecium 3.089% AR
Streptococcus gallolyticus 0.618% AR
Keystone species absent
Akkermansia muciniphila
Capacity
Shannon 3.5 · butyrate 858 CPM · SCFA 1349
H2S above band
1 vitamins below
Host & mechanisms
tissue recycling 29/100
oral translocation 1.44% AR
2 resistance genes · 1 virulence factors
Import a sample
A baseline sample re-initializes this patient's microbiome, pathways and predispositions from the measurement; a retest adds a comparison and updates them. Every theory, steering gain and dietary sensitivity downstream is then conditioned on the measured signature.
All elements · baseline → latest
Value, status vs the expected range, and the implication on health. Changes coloured: green improved / resolved, red worsened / new.
Pathogens / opportunists · 5
| Escherichia coli | 11.367 % AR · above range | 6.179 % AR · above range | expected <= 1% | In excess raises LPS load and zonulin release, opening tight junctions. |
| Klebsiella pneumoniae | 0.111 % AR · in range | 0.051 % AR · in range | expected <= 0.3% | Opportunist above range; relevant after antibiotics and in inflammation. |
| Enterococcus faecium | 0.358 % AR · in range | 3.089 % AR · above range(worsened) | expected <= 0.5% | Opportunist above range; relevant after antibiotics and in inflammation. |
| Streptococcus gallolyticus | 0.01 % AR · in range | 0.618 % AR · above range(worsened) | expected <= 0.1% | Opportunist above range; relevant after antibiotics and in inflammation. |
| Clostridioides difficile | 1.137 % AR · above range | 0.033 % AR · in range(improved) | expected <= 0.1% | Opportunist above range; relevant after antibiotics and in inflammation. |
Keystone species · 8
| Akkermansia muciniphila | 0 % AR · absent | 0 % AR · absent | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Bifidobacterium longum | 0 % AR · absent | 0.46 % AR · in range(improved) | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Butyricicoccus pullicaecorum | 0.47 % AR · in range | 0.44 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Eubacterium rectale | 0.48 % AR · in range | 0.58 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Faecalibacterium prausnitzii | 0.99 % AR · in range | 0.65 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Lactobacillus species | 0.32 % AR · in range | 1.35 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Roseburia intestinalis | 0.02 % AR · in range | 1.41 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Ruminococcus bromii | 1.42 % AR · in range | 1.44 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
Diversity · 2
| indice Shannon | 3.05 · in range | 3.5 · in range | expected >= 3.0 | Low diversity: fewer reserve metabolic routes, slower recovery after perturbation. |
| numar de specii detectate | 139 specii · in range | 148 specii · in range | expected >= 100 | Species count below reference. |
Metabolic modules · 4
| Butyrate production | 748 CPM · in range | 858 CPM · in range | expected 255.83-1089.91 CPM | Butyrate is the main colonocyte fuel and barrier signal. |
| Short Chain Fatty Acid Production | 1214 CPM · in range | 1349 CPM · in range | expected 535.03-1572.59 CPM | Total SCFA capacity. |
| GABA production | 414 CPM · in range | 453 CPM · in range | expected 87.31-766.53 CPM | Gut–brain axis capacity. |
| H2S production (sulfate reduction) | 402 CPM · above range | 462 CPM · above range | expected banda de referinta | Hydrogen sulfide above band irritates the mucosa. |
Vitamin synthesis · 7
| Vitamin B1 - Thiamin | 273 CPM · below range | 486 CPM · below range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B2 - Riboflavin | 334 CPM · below range | 3687 CPM · in range(improved) | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B5 - Pantothenic acid | 2604 CPM · in range | 4084 CPM · in range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B6 - Pyridoxine | 4403 CPM · in range | 2937 CPM · in range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B7 - Biotin | 2901 CPM · in range | 4276 CPM · in range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B9 - Folate | 3069 CPM · in range | 3259 CPM · in range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B12 - Cobalamin | 3958 CPM · in range | 4331 CPM · in range | expected 2000-5000 CPM | Microbial synthesis capacity. |
Oral translocation · 1
| Translocare orala (indice) | 2.61 % AR · above range | 1.44 % AR · in range(improved) | expected <= 2% | Oral taxa in stool: reduced gastric barrier or dysbiosis. |
Host DNA · 1
| fragmentare mixta | 156 pb · in range | 164 pb · in range | expected 150-170 pb | Host cell-free DNA fragmentation pattern. |
Tissue recycling · 1
| indice de reciclare tisulara | 33 /100 · in range | 29 /100 · in range | expected < 35 | Epithelial turnover. |
Central mechanisms · 2
| molecular_mimicry | 54 /100 · in range | 48 /100 · in range | expected < 65 | Cross-reactive antigen load. |
| estrobolome | 57 /100 · in range | 50 /100 · in range | expected < 65 | Estrogen-recycling capacity. |
Virulence factors · 2
| fimD outer membrane usher | 79 potriviri/M · present | 82 potriviri/M · present | expected absent | Virulence factor detected. |
| chuA heme/hemoglobin receptor | 69 potriviri/M · present | resolved(resolved) | expected absent | Virulence factor detected. |
Antibiotic resistance genes · 4
| sul1 | 6.1 citiri/M · present | 4.1 citiri/M · present | expected nedetectat | Resistance gene detected. |
| sul2 | 10.2 citiri/M · present | 8.4 citiri/M · present | expected nedetectat | Resistance gene detected. |
| tet(O/M/O) | 6.1 citiri/M · present | resolved(resolved) | expected nedetectat | Resistance gene detected. |
| Ecol_ampC_BLA | 3.5 citiri/M · present | resolved(resolved) | expected nedetectat | Resistance gene detected. |
Genetic predisposition · 2
| DPYD | 1.91 OR · risk variant | 3.22 OR · risk variant | expected reference genotype | Slower drug clearance |
| CYP2D6 | 3.43 OR · risk variant | 2.04 OR · risk variant | expected reference genotype | Expected exposure |