Patient P-03221
Therapy response
Improving
Tolerance
Deteriorating
GI state
Deteriorating
Inflammatory state
Deteriorating
Nutritional resilience
Declining
Discontinuation risk
53%
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and eventssolid = observed · dashed = predicted
- Day 0 ONX-7 started — Baseline state S06
- Day 50 Trajectory diverged from prediction — Observed response fell below the model's expected path.
- Day 102 GI-04 recommended — GI Support Protocol GI-04
- Day 103 Patient accepted — Started GI-04 in the companion
- Day 111 No meaningful change — GI Support Protocol GI-04
What changed?
Trajectory began diverging from predicted response on Day 50.
Primary contributors, last 14 days
- GI instability+12
- Toxicity+10
- Treatment adherence-7
- Inflammatory activity+5
- Nutritional resilience-5
What helped?
- GI Support Protocol GI-04Day 102Result: no meaningful change
LIFE OS recommendation
Dosing / Timing Recommendation DT-01
60%
probability of meaningful tolerance improvement
- 284 similar trajectories
- 77% showed improvement
- median effect visible after 5 days
Daily trackers
Molecule settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Energy level
Daily log3/10
worsening · -1.3 vs previous 14 d
Stress level
Daily log5/10
worsening · +0.9 vs previous 14 d
Pessimism score
Daily log3.8/10
worsening · +0.3 vs previous 14 d
Sleep quality
Wearable27.5/100
worsening · -10.3 vs previous 14 d
Libido
Daily log3.6/10
worsening · -0.9 vs previous 14 d
HRV
Wearable49.6 ms
worsening · -7.0 vs previous 14 d
Toxicity
Blood38.9/100
worsening · +15.8 vs previous 14 d
This trajectory is decaying — what would help, what would not
Steering view →Heading towards failing · 50 from the failing basin, 41 from restoration.
Would help
- DT-01 Dosing / Timing Recommendation77% improved among 13 similar · onset 5 d · confidence 62%
- HY-01 Hydration Protocol55% improved among 11 similar · onset 4 d · confidence 62%
- ME-01 Monitoring Escalation100% improved among 6 similar · onset 3 d · confidence 62%
- More proteinGI -5.1 next day on high-intake days · n 17
Would not help
- GI-04 GI Support Protocolalready tried, no meaningful change
- Keep fat lowGI +4.4 next day on high-intake days · n 21
- Keep lactose lowGI +4 next day on high-intake days · n 26
- Keep alcohol lowGI +3.9 next day on high-intake days · n 25
State influencers · digestive
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-5.1supporter · 95%
- Dietary fat load+4.4detractor · 95%
- Lactose+4detractor · 95%
- Alcohol+3.9detractor · 95%
- Caffeine+1.2no signal · 26%
- Histamine load-0.4no signal · 15%
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
Pathways under pressure
- Butyrate / short-chain fatty acid production ↓80
- MicrobiomeButyrate capacity 39/100
- MicrobiomeF. prausnitzii depleted
- Daily logFibre intake low in recent food logs
- Inflammatory signalling ↑45
- MicrobiomeBacteroides fragilis expansion
- BloodInflammatory load index 46
- Autonomic recovery ↓45
- WearableResting HR 79 bpm
- WearableShort sleep window
- Mucosal barrier integrity ↓30
- Daily logGI symptom score 49 and rising
- WearableSleep 5.2 h, below personal baseline
DNA
Fictional pharmacogenomic panel
- CYP2D6 Normal metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
Microbiome
Shannon diversity 2.7 · butyrate capacity 39/100
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
Wearable, last 14 days
daily evolution fed into the runtime
- HRV
- 51 ms
- Sleep
- 5.5 h
- Steps
- 5,438
- Resting HR
- 76 bpm
Daily log: GI score 49, nutritional resilience 43, adherence 88.
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
What to eat
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
What to do
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
What to take
- Take the scheduled dose as agreed with your care team
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.