DeepGene damage signature
SyntheticSynthetic demo data2 samples: baseline day 0 · retest day 90
Damage score · retest day 90
37/100
vs baseline (day 0)
-20
8 improved · 0 worsened
synthetic signature · consistent with this patient's biology
- 2 opportunists above range: Escherichia coli, Klebsiella pneumoniae
- 2 keystone species absent
- Shannon 2.77 (expected ≥ 3)
- 6 resistance genes
Pathogens / opportunists2/5
↓ from 5
Keystone species2/8
↓ from 3
Diversity1/2
Metabolic modules0/4
Vitamin synthesis2/7
↓ from 3
Oral translocation1/1
Host DNA0/1
Tissue recycling0/1
↓ from 1
Central mechanisms0/2
Virulence factors2/2
↓ from 3
Antibiotic resistance genes6/6
↓ from 7
Genetic predisposition2/2
Opportunists above range
Escherichia coli 14.421% AR
Klebsiella pneumoniae 4.326% AR
Keystone species absent
Akkermansia muciniphila, Bifidobacterium longum
Capacity
Shannon 2.77 · butyrate 648 CPM · SCFA 1072
2 vitamins below
Host & mechanisms
tissue recycling 32/100
oral translocation 3.29% AR
6 resistance genes · 2 virulence factors
Import a sample
A baseline sample re-initializes this patient's microbiome, pathways and predispositions from the measurement; a retest adds a comparison and updates them. Every theory, steering gain and dietary sensitivity downstream is then conditioned on the measured signature.
All elements · baseline → latest
Value, status vs the expected range, and the implication on health. Changes coloured: green improved / resolved, red worsened / new.
Pathogens / opportunists · 5
| Escherichia coli | 17.281 % AR · above range | 14.421 % AR · above range | expected <= 1% | In excess raises LPS load and zonulin release, opening tight junctions. |
| Klebsiella pneumoniae | 5.184 % AR · above range | 4.326 % AR · above range | expected <= 0.3% | Opportunist above range; relevant after antibiotics and in inflammation. |
| Enterococcus faecium | 8.641 % AR · above range | 0.311 % AR · in range(improved) | expected <= 0.5% | Opportunist above range; relevant after antibiotics and in inflammation. |
| Streptococcus gallolyticus | 1.728 % AR · above range | 0.056 % AR · in range(improved) | expected <= 0.1% | Opportunist above range; relevant after antibiotics and in inflammation. |
| Clostridioides difficile | 1.728 % AR · above range | 0.073 % AR · in range(improved) | expected <= 0.1% | Opportunist above range; relevant after antibiotics and in inflammation. |
Keystone species · 8
| Akkermansia muciniphila | 0 % AR · absent | 0 % AR · absent | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Bifidobacterium longum | 0 % AR · absent | 0 % AR · absent | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Butyricicoccus pullicaecorum | 0 % AR · absent | 0.78 % AR · in range(improved) | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Eubacterium rectale | 0.92 % AR · in range | 1.41 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Faecalibacterium prausnitzii | 0.88 % AR · in range | 1.48 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Lactobacillus species | 1.09 % AR · in range | 0.7 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Roseburia intestinalis | 0.81 % AR · in range | 0.91 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
| Ruminococcus bromii | 1.31 % AR · in range | 0.61 % AR · in range | expected 0.15-2.24% | Keystone butyrate producer / mucin specialist. |
Diversity · 2
| indice Shannon | 2.86 · below range | 2.77 · below range | expected >= 3.0 | Low diversity: fewer reserve metabolic routes, slower recovery after perturbation. |
| numar de specii detectate | 115 specii · in range | 116 specii · in range | expected >= 100 | Species count below reference. |
Metabolic modules · 4
| Butyrate production | 599 CPM · in range | 648 CPM · in range | expected 255.83-1089.91 CPM | Butyrate is the main colonocyte fuel and barrier signal. |
| Short Chain Fatty Acid Production | 1043 CPM · in range | 1072 CPM · in range | expected 535.03-1572.59 CPM | Total SCFA capacity. |
| GABA production | 344 CPM · in range | 353 CPM · in range | expected 87.31-766.53 CPM | Gut–brain axis capacity. |
| H2S production (sulfate reduction) | 138 CPM · in range | 107 CPM · in range | expected banda de referinta | Hydrogen sulfide above band irritates the mucosa. |
Vitamin synthesis · 7
| Vitamin B1 - Thiamin | 256 CPM · below range | 377 CPM · below range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B2 - Riboflavin | 396 CPM · below range | 401 CPM · below range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B5 - Pantothenic acid | 403 CPM · below range | 2513 CPM · in range(improved) | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B6 - Pyridoxine | 2809 CPM · in range | 2696 CPM · in range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B7 - Biotin | 2570 CPM · in range | 4352 CPM · in range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B9 - Folate | 3487 CPM · in range | 3308 CPM · in range | expected 2000-5000 CPM | Microbial synthesis capacity. |
| Vitamin B12 - Cobalamin | 3032 CPM · in range | 3774 CPM · in range | expected 2000-5000 CPM | Microbial synthesis capacity. |
Oral translocation · 1
| Translocare orala (indice) | 3.94 % AR · above range | 3.29 % AR · above range | expected <= 2% | Oral taxa in stool: reduced gastric barrier or dysbiosis. |
Host DNA · 1
| fragmentare mixta | 158 pb · in range | 162 pb · in range | expected 150-170 pb | Host cell-free DNA fragmentation pattern. |
Tissue recycling · 1
| indice de reciclare tisulara | 39 /100 · above range | 32 /100 · in range(improved) | expected < 35 | Epithelial turnover. |
Central mechanisms · 2
| molecular_mimicry | 62 /100 · in range | 58 /100 · in range | expected < 65 | Cross-reactive antigen load. |
| estrobolome | 57 /100 · in range | 62 /100 · in range | expected < 65 | Estrogen-recycling capacity. |
Virulence factors · 3
| fimD outer membrane usher | 38 potriviri/M · present | 35 potriviri/M · present | expected absent | Virulence factor detected. |
| chuA heme/hemoglobin receptor | 87 potriviri/M · present | 68 potriviri/M · present | expected absent | Virulence factor detected. |
| irp2 yersiniabactin synthetase | 89 potriviri/M · present | resolved(resolved) | expected absent | Virulence factor detected. |
Antibiotic resistance genes · 7
| sul1 | 7.8 citiri/M · present | 2.2 citiri/M · present | expected nedetectat | Resistance gene detected. |
| sul2 | 5.5 citiri/M · present | 7.6 citiri/M · present | expected nedetectat | Resistance gene detected. |
| tet(O/M/O) | 2 citiri/M · present | 10.1 citiri/M · present | expected nedetectat | Resistance gene detected. |
| Ecol_ampC_BLA | 8.7 citiri/M · present | 9.3 citiri/M · present | expected nedetectat | Resistance gene detected. |
| aadA | 4.3 citiri/M · present | 4.7 citiri/M · present | expected nedetectat | Resistance gene detected. |
| dfrA1 | 9.4 citiri/M · present | 9.2 citiri/M · present | expected nedetectat | Resistance gene detected. |
| APH(6)-Id | 7.4 citiri/M · present | resolved(resolved) | expected nedetectat | Resistance gene detected. |
Genetic predisposition · 2
| IL6 | 2.45 OR · risk variant | 3.03 OR · risk variant | expected reference genotype | Higher inflammatory tone |
| CYP2D6 | 1.8 OR · risk variant | 3.04 OR · risk variant | expected reference genotype | Higher exposure at standard dose |