Patient P-02091
Metabolic response 63 at the day-84 endpoint (observed).
Responding: response probability 59%, metabolic response 58 today; biology is not blocking the drug.
No side effect starting: nausea / gi symptoms 19, tolerability burden 27, no drift from the model.
54 of 61 scheduled doses in the last 60 days are biologically confirmed (89%); 7 were logged but show no dose signature. Dose signature: resting HR +3 bpm, HRV −7 ms.
Trajectory is stable relative to similar patients; keep the current content.
- 🍽Keep meals regular; three to four moderate portions spaced through the day
- 🍽Include a cooked vegetable portion with each main meal
- ✓Log the daily check-in; one line is enough
- ✓A 15-minute walk after lunch
- 💊Take the dose at the same time relative to your evening meal
- 💊No additional supplements this week
Adherence is not the problem.
sleep quality falling under 35 while GI rises
P-02091 is on day 138 of META-24 (MR, baseline S02): response declining, tolerance favorable, GI improving. Over 14 days response moved -7 and GI -5; discontinuation risk is 16%. The state is in the restoration basin, heading towards restoration.
Biology sets the gain: Low microbial diversity; butyrate capacity 47/100, diversity 2.8. Pushing it down: Enterococcus faecium 11.684% (LPS load) (-32.7), 4 keystone species absent (-24.3), Tissue recycling 51/100 (-15.6). Pulling it up: Protein (supports) (+14.5), Butyrate producers intact (+13.9). From the daily log: protein -3.4 GI next day, simple carbs +2.4 GI next day.
No action has been tried yet.
No action is indicated now; the trajectory is stable relative to similar patients.
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and events- Day 0 META-24 started — Baseline state S02
What changed?
Trajectory is tracking the baseline prediction.
- Inflammatory activity-12
- GI instability-5
- Treatment adherence+5
- Toxicity+3
What helped?
No interventions yet.
Daily trackers
Asset settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Heading towards restoration · 74 from the failing basin, 20 from restoration.
- No untried action with strong evidence. Compose one from primitives.
- More proteinGI -3.4 next day on high-intake days · n 20
- Keep simple carbs lowGI +2.4 next day on high-intake days · n 21
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-3.4supporter · 95%
- Simple carbohydrates+2.4detractor · 88%
- Ultra-processed food+1.4no signal · 44%
- Insoluble fibre-0.2no signal · 15%
- Dietary fat load0no signal · 15%
- Alcohol0no signal · 15%
DeepGene damage signature
The metagenomic + host-DNA read-out that initializes this patient's biology and, on retest, measures whether the steering worked.
- 1 opportunist above range: Enterococcus faecium
- 4 keystone species absent
- Shannon 2.44 (expected ≥ 3)
- 7 resistance genes
- Tissue recycling index 51
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
- Autonomic recovery ↑45
- WearableResting HR 73 bpm
- Wearable3,006 steps/day
- Inflammatory signalling ↓35
- MicrobiomeBacteroides fragilis expansion
- WearableHRV 31 ms, trending down
- CYP2D6 Normal metabolizerExpected exposure
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
- HRV
- 32 ms
- Sleep
- 7.9 h
- Steps
- 3,217
- Resting HR
- 72 bpm
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Keep fibre steady; no new sources this week
- Eat slowly and stop at comfortable fullness — smaller volume, more often
- Log the daily check-in; one line is enough
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
- Take the dose at the same time relative to your evening meal
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02129 | 53% | S08 | BR-03 | improved | 59 |
| P-02092 | 52% | S04 | ME-01 | improved | 67 |
| P-02147 | 48% | S14 | SC-12 | improved | 64 |
| P-02135 | 47% | S06 | BR-03 | improved | 70 |
| P-02453 | 42% | S18 | DT-01 | improved | 53 |
| P-02055 | 41% | S07 | SC-12 | improved | 57 |
| P-02494 | 41% | S01 | DT-01 | improved | 66 |
| P-02617 | 41% | S17 | DT-01 | improved | 55 |
| P-02627 | 41% | S11 | AD-05 | improved | 59 |
| P-02106 | 39% | S19 | DT-01 | improved | 50 |
| P-02498 | 39% | S10 | ME-01 | improved | 67 |
| P-02068 | 38% | S05 | HY-01 | improved | 58 |