Patient P-02311
Metabolic response 83 at the day-84 endpoint (observed).
Responding: response probability 82%, metabolic response 81 today; biology is not blocking the drug.
No side effect starting: nausea / gi symptoms 21, tolerability burden 20, no drift from the model.
53 of 61 scheduled doses in the last 60 days are biologically confirmed (87%); 5 were logged but show no dose signature. Dose signature: resting HR +3 bpm, HRV −10 ms.
Trajectory is stable relative to similar patients; keep the current content.
- 🍽Keep meals regular; three to four moderate portions spaced through the day
- 🍽Include a cooked vegetable portion with each main meal
- ✓Log the daily check-in; one line is enough
- ✓A 15-minute walk after lunch
- 💊Take the dose at the same time relative to your evening meal
- 💊No additional supplements this week
Adherence is not the problem.
sleep quality falling under 35 while GI rises
P-02311 is on day 143 of META-24 (SR, baseline S02): response improving, tolerance favorable, GI favorable. Over 14 days response moved +8 and GI -1; discontinuation risk is 18%. The state is in the restoration basin, heading towards restoration.
Biology sets the gain: FUT2 non-secretor, Poor metabolizer; butyrate capacity 80/100, diversity 3.7. Pushing it down: Escherichia coli 6.912% (LPS load) (-26.9), Poor metabolizer (-24.4), FUT2 non-secretor (-20.4). Pulling it up: Protein (supports) (+17.5), Butyrate producers intact (+14.3). From the daily log: protein -4.1 GI next day, simple carbs -2.9 GI next day.
No action has been tried yet.
No action is indicated now; the trajectory is stable relative to similar patients.
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and events- Day 0 META-24 started — Baseline state S02
What changed?
Trajectory is tracking the baseline prediction.
- Inflammatory activity+9
- Toxicity+3
- Nutritional resilience-2
What helped?
No interventions yet.
Daily trackers
Asset settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Heading towards restoration · 83 from the failing basin, 9 from restoration.
- Protein (supports)perturbation · steering +17.5
- Butyrate producers intacthidden · steering +14.3
- Simple carbohydrates (supports)perturbation · steering +10.2
- Proteinsupporter · GI -4.1 next day
- Simple carbohydratessupporter · GI -2.9 next day
- Escherichia coli 6.912% (LPS load)hidden · steering -26.9
- Poor metabolizerhidden · steering -24.4
- FUT2 non-secretorhidden · steering -20.4
- Antibiotic courseperturbation · steering -4.7
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-4.1supporter · 95%
- Simple carbohydrates-2.9supporter · 70%
- Dietary fat load+1no signal · 21%
- Insoluble fibre+0.7no signal · 15%
- Alcohol-0.4no signal · 15%
- Ultra-processed food+0.1no signal · 15%
DeepGene damage signature
The metagenomic + host-DNA read-out that initializes this patient's biology and, on retest, measures whether the steering worked.
- 2 opportunists above range: Escherichia coli, Klebsiella pneumoniae
- 1 keystone species absent
- 2 resistance genes
- Host DNA fragmentation atypical
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
- Mucosal barrier integrity ↓40
- DNAFUT2 non-secretor lowers mucosal fucosylation
- WearableSleep 6.1 h, below personal baseline
- Drug metabolism and exposure ↑40
- DNACYP2D6 poor metabolizer → higher exposure
- Autonomic recovery ↓20
- WearableShort sleep window
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Poor metabolizerHigher exposure at standard dose
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeNormal
- HRV
- 60 ms
- Sleep
- 6.2 h
- Steps
- 3,808
- Resting HR
- 62 bpm
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Keep fibre steady; no new sources this week
- Eat slowly and stop at comfortable fullness — smaller volume, more often
- Log the daily check-in; one line is enough
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
- Take the dose at the same time relative to your evening meal
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.