Patient P-02537
Metabolic response 63 at the day-84 endpoint (observed).
Responding: response probability 47%, metabolic response 49 today; biology is not blocking the drug.
Drift detected on day 25 (HRV −11 ms, resting HR +4 bpm, sleep −0.9 h, nausea / gi symptoms +20, inflammatory load +12); the side effect would have been reported on day 80 — 55 days of warning.
21 of 61 scheduled doses in the last 60 days are biologically confirmed (34%); 1 were logged but show no dose signature. Dose signature: resting HR +3 bpm, HRV −8 ms.
CGM mean 155 mg/dL and stable: dietary support targets the glucose pattern first.
57% of 284 similar trajectories improved after NP-02; if this one does, discontinuation risk is expected to fall from 96% to ~77%. Keeping fat low is worth 4.8 GI points a day on its own. Losing this patient costs €6k; the intervention costs €45.
- 🍽Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- 🍽Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- ✓Track each bowel movement today: time, stool form, urgency, overnight waking
- ✓A 15-minute walk after lunch
- 💊Take the dose at the same time relative to your evening meal
- 💊Electrolyte solution, one sachet after any loose stool
Dose is being missed; nothing else works until this is fixed.
GI burden above 78 for 3 days within the onset window
P-02537 is on day 170 of META-24 (EC-03, baseline S14): response stable, tolerance deteriorating, GI unstable. Over 14 days response moved +4 and GI -1; discontinuation risk is 96%. The state is between basins, heading towards restoration, after diverging from the model on day 25.
Biology sets the gain: FUT2 non-secretor, IL6 high-expression variant, Low butyrate capacity, Low microbial diversity, Baseline state S14, Cluster EC-03 (high response / high intolerance), Adherence < 60%; butyrate capacity 31/100, diversity 2.5. Pushing it down: Escherichia coli 38.323% (LPS load) (-49.2), Low butyrate capacity (-38.7), 7 keystone species absent (-28.9). Pulling it up: Protein (supports) (+27.7). From the daily log: protein -5.4 GI next day, fat +4.8 GI next day, ultra-processed +4.5 GI next day, simple carbs +4.1 GI next day.
No action has been tried yet.
Next: NP-02 — 57% of 284 similar trajectories improved, 55% probability here. CGM mean 155 mg/dL and stable: dietary support targets the glucose pattern first. This would be contradicted by a further GI rise within the onset window or falling adherence.
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and events- Day 0 META-24 started — Baseline state S14
- Day 25 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 25.
- Toxicity+10
- Nutritional resilience-7
- Inflammatory activity+3
- Treatment adherence-2
What helped?
No interventions yet.
- 284 similar trajectories
- 57% showed improvement
- median effect visible after 10 days
CGM mean 155 mg/dL and stable: dietary support targets the glucose pattern first.
Daily trackers
Asset settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Heading towards restoration · 26 from the failing basin, 73 from restoration.
- ME-01 Monitoring Escalation100% improved among 45 similar · onset 3 d · confidence 75%
- GI-04 GI Support Protocol67% improved among 67 similar · onset 8 d · confidence 97%
- NP-02 Dietary Support Protocol61% improved among 38 similar · onset 10 d · confidence 75%
- More proteinGI -5.4 next day on high-intake days · n 22
- Keep fat lowGI +4.8 next day on high-intake days · n 25
- Keep ultra-processed lowGI +4.5 next day on high-intake days · n 19
- Keep simple carbs lowGI +4.1 next day on high-intake days · n 21
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-5.4supporter · 95%
- Dietary fat load+4.8detractor · 95%
- Ultra-processed food+4.5detractor · 95%
- Simple carbohydrates+4.1detractor · 95%
- Insoluble fibre+3.4detractor · 83%
- Alcohol+3.2detractor · 76%
DeepGene damage signature
The metagenomic + host-DNA read-out that initializes this patient's biology and, on retest, measures whether the steering worked.
- 4 opportunists above range: Escherichia coli, Klebsiella pneumoniae, Streptococcus gallolyticus
- 7 keystone species absent
- Shannon 1.34 (expected ≥ 3)
- Butyrate production 169 CPM, below range
- 12 resistance genes
- Host DNA fragmentation atypical
- Tissue recycling index 73
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
- Autonomic recovery ↓65
- WearableResting HR 81 bpm
- Wearable3,127 steps/day
- WearableShort sleep window
- Butyrate / short-chain fatty acid production ↓55
- MicrobiomeButyrate capacity 31/100
- Daily logFibre intake low in recent food logs
- Mucosal barrier integrity ↓50
- DNAFUT2 non-secretor lowers mucosal fucosylation
- Daily logGI symptom score 70 and rising
- Inflammatory signalling ↑50
- DNAIL6 -174 variant raises baseline inflammatory tone
- BloodInflammatory load index 65
- Drug metabolism and exposure ↑20
- BloodToxicity index 53
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Rapid metabolizerExpected exposure
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
- HRV
- 50 ms
- Sleep
- 6.4 h
- Steps
- 3,238
- Resting HR
- 79 bpm
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
- Prepare a plain, low-fat pasta or rice meal and note how it feels afterwards
- Choose a freshly cooked, lean protein; avoid frying, rich sauces and leftovers for now
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
- Track each bowel movement today: time, stool form, urgency, overnight waking
- A 15-minute walk after lunch
- Protect a 7.5-hour sleep window; screens off 30 minutes before
- Keep hydration steady: small amounts through the day rather than large volumes at once
- Take the dose at the same time relative to your evening meal
- Electrolyte solution, one sachet after any loose stool
- Fictional demo item: oral nutrition supplement with lunch
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02534 | 59% | S14 | NP-02 | improved | 51 |
| P-02076 | 57% | S14 | SC-12 | improved | 48 |
| P-02656 | 49% | S14 | ME-01 | improved | 40 |
| P-02369 | 46% | S14 | SC-12 | improved | 47 |
| P-02506 | 46% | S10 | ME-01 | improved | 41 |
| P-02028 | 45% | S16 | ME-01 | improved | 49 |
| P-02415 | 45% | S05 | ME-01 | improved | 42 |
| P-02262 | 44% | S11 | NP-02 | improved | 46 |
| P-02581 | 43% | S14 | SC-12 | improved | 47 |
| P-02628 | 43% | S14 | SC-12 | improved | 48 |
| P-02239 | 42% | S16 | NP-02 | improved | 44 |
| P-02667 | 42% | S14 | ME-01 | improved | 45 |