Patient P-02694
Metabolic response 66 at the day-84 endpoint (observed).
Responding: response probability 60%, metabolic response 59 today; biology is not blocking the drug.
Drift detected on day 127 (sleep −0.8 h); nothing reported yet — the window to act is open.
55 of 61 scheduled doses in the last 60 days are biologically confirmed (90%); 4 were logged but show no dose signature. Dose signature: resting HR +7 bpm, HRV −8 ms.
Trajectory is stable relative to similar patients; keep the current content.
- 🍽Keep meals regular; three to four moderate portions spaced through the day
- 🍽Include a cooked vegetable portion with each main meal
- ✓Log the daily check-in; one line is enough
- ✓Keep the current walking rhythm
- 💊Take the dose at the same time relative to your evening meal
- 💊No additional supplements this week
Adherence is not the problem.
sleep quality falling under 35 while GI rises
P-02694 is on day 177 of META-24 (MR, baseline S17): response declining, tolerance favorable, GI deteriorating. Over 14 days response moved -5 and GI +4; discontinuation risk is 24%. The state is between basins, heading towards failing, after diverging from the model on day 127.
Biology sets the gain: FUT2 non-secretor; butyrate capacity 55/100, diversity 3.7. Pushing it down: Escherichia coli 13.095% (LPS load) (-42.6), FUT2 non-secretor (-24.3), Bacteroides fragilis elevated (-16.8). Pulling it up: Protein (supports) (+18.7), Butyrate producers intact (+17.1). From the daily log: protein -3.5 GI next day.
No action has been tried yet.
No action is indicated now; the trajectory is stable relative to similar patients.
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and events- Day 0 META-24 started — Baseline state S17
- Day 127 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 127.
- GI instability+4
- Nutritional resilience+4
- Toxicity+3
What helped?
No interventions yet.
Daily trackers
Asset settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Heading towards failing · 67 from the failing basin, 22 from restoration.
- No untried action with strong evidence. Compose one from primitives.
- More proteinGI -3.5 next day on high-intake days · n 21
- Nothing clearly counter-productive in the record.
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-3.5supporter · 95%
- Simple carbohydrates+0.9no signal · 25%
- Insoluble fibre-0.9no signal · 26%
- Dietary fat load+0.5no signal · 15%
- Ultra-processed food+0.5no signal · 17%
- Alcohol-0.4no signal · 15%
DeepGene damage signature
The metagenomic + host-DNA read-out that initializes this patient's biology and, on retest, measures whether the steering worked.
- 4 opportunists above range: Escherichia coli, Klebsiella pneumoniae, Enterococcus faecium
- 2 keystone species absent
- Shannon 2.76 (expected ≥ 3)
- 4 resistance genes
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
- Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Autonomic recovery ↑25
- WearableResting HR 77 bpm
- Inflammatory signalling ↑20
- MicrobiomeBacteroides fragilis expansion
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- CYP2D6 Intermediate metabolizerExpected exposure
- GLP1R rs6923761 AAltered receptor sensitivity
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiNormal
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeHigh
- HRV
- 41 ms
- Sleep
- 7.8 h
- Steps
- 8,320
- Resting HR
- 76 bpm
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Keep fibre steady; no new sources this week
- Eat slowly and stop at comfortable fullness — smaller volume, more often
- Log the daily check-in; one line is enough
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
- Take the dose at the same time relative to your evening meal
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.