Patient P-02099
Metabolic response 65 at the day-84 endpoint (observed).
Responding: response probability 60%, metabolic response 59 today; biology is not blocking the drug.
Drift detected on day 27 (sleep −0.7 h, nausea / gi symptoms +7); nothing reported yet — the window to act is open.
47 of 61 scheduled doses in the last 60 days are biologically confirmed (77%); 13 were logged but show no dose signature. Dose signature: resting HR +6 bpm, HRV −7 ms.
Trajectory is stable relative to similar patients; keep the current content.
- 🍽Keep meals regular; three to four moderate portions spaced through the day
- 🍽Include a cooked vegetable portion with each main meal
- ✓Log the daily check-in; one line is enough
- ✓Keep the current walking rhythm
- 💊Take the dose at the same time relative to your evening meal
- 💊No additional supplements this week
Adherence is not the problem.
sleep quality falling under 35 while GI rises
P-02099 is on day 118 of META-24 (MR, baseline S17): response stable, tolerance deteriorating, GI deteriorating. Over 14 days response moved 0 and GI +5; discontinuation risk is 23%. The state is in the restoration basin, heading towards failing, after diverging from the model on day 27.
Butyrate capacity 57/100, diversity 3.6, intermediate metabolizer. Pushing it down: Escherichia coli 10.979% (LPS load) (-28), Bacteroides fragilis elevated (-12.1), Alcohol (-8.4). Pulling it up: Butyrate producers intact (+12.2), Protein (supports) (+12). From the daily log: protein -3.5 GI next day, alcohol +2.4 GI next day.
No action has been tried yet.
No action is indicated now; the trajectory is stable relative to similar patients.
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and events- Day 0 META-24 started — Baseline state S17
- Day 27 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 27.
- GI instability+5
- Nutritional resilience-5
- Treatment adherence+4
- Toxicity+4
- Inflammatory activity-2
What helped?
No interventions yet.
Daily trackers
Asset settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Heading towards failing · 69 from the failing basin, 21 from restoration.
- No untried action with strong evidence. Compose one from primitives.
- More proteinGI -3.5 next day on high-intake days · n 17
- Keep alcohol lowGI +2.4 next day on high-intake days · n 16
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-3.5supporter · 95%
- Alcohol+2.4detractor · 77%
- Simple carbohydrates-1.5no signal · 49%
- Insoluble fibre+0.7no signal · 15%
- Ultra-processed food-0.7no signal · 25%
- Dietary fat load0no signal · 15%
DeepGene damage signature
The metagenomic + host-DNA read-out that initializes this patient's biology and, on retest, measures whether the steering worked.
- 2 opportunists above range: Escherichia coli, Enterococcus faecium
- 2 keystone species absent
- 5 resistance genes
- Host DNA fragmentation atypical
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
- Butyrate / short-chain fatty acid production ↓25
- MicrobiomeF. prausnitzii depleted
- Inflammatory signalling ↓20
- MicrobiomeBacteroides fragilis expansion
- CYP2D6 Intermediate metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
- Akkermansia muciniphilaNormal
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisHigh
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
- HRV
- 65 ms
- Sleep
- 6.7 h
- Steps
- 7,131
- Resting HR
- 64 bpm
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Eat slowly and stop at comfortable fullness — smaller volume, more often
- Log the daily check-in; one line is enough
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
- Take the dose at the same time relative to your evening meal
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-02516 | 53% | S17 | BR-03 | improved | 55 |
| P-02055 | 51% | S07 | SC-12 | improved | 57 |
| P-02627 | 51% | S11 | AD-05 | improved | 59 |
| P-02572 | 48% | S03 | ME-01 | improved | 55 |
| P-02287 | 42% | S05 | DT-01 | improved | 53 |
| P-02429 | 42% | S20 | GI-04 | improved | 52 |
| P-02455 | 42% | S04 | GI-04 | improved | 58 |
| P-02129 | 41% | S08 | BR-03 | improved | 59 |
| P-02498 | 41% | S10 | ME-01 | improved | 67 |
| P-02251 | 40% | S14 | HY-01 | improved | 50 |
| P-02193 | 39% | S14 | DT-01 | improved | 49 |
| P-02690 | 39% | S17 | HY-01 | improved | 45 |