600 patients66,869 observations120 daysLIVE

30 trajectories in Delayed loss of response

Trajectories

Synthetic demo data

All Strong responders · 132 Moderate responders · 102 Non-responders · 54 Early toxicity · 36 Late toxicity · 30 Delayed loss of response · 30 Resilient responder · 32 High response / high intolerance · 184

Mean lived trajectory vs baseline model

days with fewer than 10 patients are cut

solid = observed · dashed = predicted

Individual trajectories, highest risk first

P-01348D117 · risk 62%

UnstableDeterioratingresp 25

P-01689D105 · risk 33%

ImprovingDeterioratingresp 50

P-01345D108 · risk 28%

UnstableDeterioratingresp 30

P-01650D95 · risk 27%

UnstableDeterioratingresp 41

P-01847D116 · risk 24%

UnstableDeterioratingresp 37

P-01832D114 · risk 21%

UnstableImprovingresp 42

P-01899D102 · risk 20%

UnstableDeterioratingresp 37

P-01846D110 · risk 18%

UnstableImprovingresp 37

P-01350D115 · risk 16%

UnstableImprovingresp 34

P-01848D113 · risk 15%

UnstableImprovingresp 23

P-01722D113 · risk 14%

UnstableImprovingresp 36

P-01401D115 · risk 13%

UnstableImprovingresp 34