600 patients66,869 observations120 daysLIVE

102 trajectories in Moderate responders

Trajectories

Synthetic demo data

All Strong responders · 132 Moderate responders · 102 Non-responders · 54 Early toxicity · 36 Late toxicity · 30 Delayed loss of response · 30 Resilient responder · 32 High response / high intolerance · 184

Mean lived trajectory vs baseline model

days with fewer than 10 patients are cut

solid = observed · dashed = predicted

Individual trajectories, highest risk first

P-01631D112 · risk 63%

StableDeterioratingresp 59

P-01343D99 · risk 43%

DecliningDeterioratingresp 55

P-01375D108 · risk 35%

FavorableDeterioratingresp 64

P-01461D120 · risk 31%

FavorableDeterioratingresp 61

P-01750D108 · risk 29%

FavorableDeterioratingresp 69

P-01404D115 · risk 26%

StableDeterioratingresp 58

P-01729D92 · risk 24%

ImprovingDeterioratingresp 65

P-01515D117 · risk 21%

DecliningFavorableresp 66

P-01620D109 · risk 19%

DecliningFavorableresp 63

P-01669D117 · risk 17%

DecliningDeterioratingresp 45

P-01741D117 · risk 15%

DecliningImprovingresp 55

P-01783D120 · risk 14%

DecliningImprovingresp 54