600 patients66,869 observations120 daysLIVE

30 trajectories in Late toxicity

Trajectories

Synthetic demo data

All Strong responders · 132 Moderate responders · 102 Non-responders · 54 Early toxicity · 36 Late toxicity · 30 Delayed loss of response · 30 Resilient responder · 32 High response / high intolerance · 184

Mean lived trajectory vs baseline model

days with fewer than 10 patients are cut

solid = observed · dashed = predicted

Individual trajectories, highest risk first

P-01373D92 · risk 96%

FavorableUnstableresp 61

P-01388D104 · risk 92%

StableUnstableresp 59

P-01877D118 · risk 89%

FavorableUnstableresp 67

P-01697D119 · risk 73%

StableUnstableresp 55

P-01514D109 · risk 65%

ImprovingUnstableresp 63

P-01805D119 · risk 62%

DecliningUnstableresp 46

P-01470D112 · risk 59%

DecliningUnstableresp 55

P-01469D116 · risk 58%

StableUnstableresp 58

P-01623D109 · risk 56%

StableUnstableresp 52

P-01600D116 · risk 54%

StableImprovingresp 51

P-01794D116 · risk 54%

StableUnstableresp 54

P-01768D100 · risk 53%

DecliningStableresp 53