600 patients66,869 observations120 daysLIVE

36 trajectories in Early toxicity

Trajectories

Synthetic demo data

All Strong responders · 132 Moderate responders · 102 Non-responders · 54 Early toxicity · 36 Late toxicity · 30 Delayed loss of response · 30 Resilient responder · 32 High response / high intolerance · 184

Mean lived trajectory vs baseline model

days with fewer than 10 patients are cut

solid = observed · dashed = predicted

Individual trajectories, highest risk first

P-01884D108 · risk 53%

StableDeterioratingresp 54

P-01871D110 · risk 25%

StableDeterioratingresp 57

P-01823D114 · risk 22%

StableFavorableresp 57

P-01701D117 · risk 16%

StableFavorableresp 55

P-01609D117 · risk 15%

StableImprovingresp 48

P-01487D92 · risk 14%

StableFavorableresp 48

P-01644D96 · risk 13%

StableImprovingresp 50

P-01555D100 · risk 12%

StableFavorableresp 56

P-01522D111 · risk 11%

ImprovingImprovingresp 62

P-01790D91 · risk 11%

UnstableImprovingresp 41

P-01381D108 · risk 10%

ImprovingImprovingresp 68

P-01596D117 · risk 8%

ImprovingImprovingresp 51