Patient P-03091
Immune response 60 at the day-84 endpoint (observed).
Responding: response probability 61%, immune response 62 today; biology is not blocking the drug.
No side effect starting: immune-related gi adverse events 19, immune-related toxicity 19, no drift from the model.
4 of 4 scheduled doses in the last 60 days are biologically confirmed (100%). Dose signature: resting HR +4 bpm, HRV −6 ms.
Trajectory is stable relative to similar patients; keep the current content.
- 🍽Keep meals regular; three to four moderate portions spaced through the day
- 🍽Include a cooked vegetable portion with each main meal
- ✓Log the daily check-in; one line is enough
- ✓A 15-minute walk after lunch
- 💊Take the scheduled dose as agreed with your care team
- 💊No additional supplements this week
Adherence is not the problem.
sleep quality falling under 35 while GI rises
P-03091 is on day 148 of ONX-7 (MR, baseline S15): response favorable, tolerance favorable, GI favorable. Over 14 days response moved 0 and GI 0; discontinuation risk is 15%. The state is in the restoration basin, heading towards failing.
Biology sets the gain: FUT2 non-secretor, IL6 high-expression variant; butyrate capacity 75/100, diversity 3.4. Pushing it down: FUT2 non-secretor (-20.9), Clostridioides difficile 0.809% (LPS load) (-18.7), Histamine load (-15.2). Pulling it up: Protein (supports) (+14.8), Butyrate producers intact (+14.7). From the daily log: histamine +3.6 GI next day, protein -3.2 GI next day, lactose +2.4 GI next day.
No action has been tried yet.
No action is indicated now; the trajectory is stable relative to similar patients.
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and events- Day 0 ONX-7 started — Baseline state S15
What changed?
Trajectory is tracking the baseline prediction.
- Inflammatory activity+5
- Nutritional resilience+4
- Toxicity-2
What helped?
No interventions yet.
Daily trackers
Asset settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Heading towards failing · 72 from the failing basin, 18 from restoration.
- No untried action with strong evidence. Compose one from primitives.
- More proteinGI -3.2 next day on high-intake days · n 20
- Keep histamine lowGI +3.6 next day on high-intake days · n 21
- Keep lactose lowGI +2.4 next day on high-intake days · n 16
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Histamine load+3.6detractor · 95%
- Protein-3.2supporter · 95%
- Lactose+2.4detractor · 74%
- Caffeine-1.4no signal · 42%
- Dietary fat load-1.2no signal · 28%
- Alcohol+0.1no signal · 15%
DeepGene damage signature
The metagenomic + host-DNA read-out that initializes this patient's biology and, on retest, measures whether the steering worked.
- 1 opportunist above range: Clostridioides difficile
- 1 keystone species absent
- 5 resistance genes
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
- Mucosal barrier integrity ↓60
- DNAFUT2 non-secretor lowers mucosal fucosylation
- MicrobiomeAkkermansia low → thinner mucus layer
- Inflammatory signalling ↑25
- DNAIL6 -174 variant raises baseline inflammatory tone
- Butyrate / short-chain fatty acid production ↓25
- MicrobiomeF. prausnitzii depleted
- FUT2 rs601338 AA (non-secretor)Reduced mucosal fucosylation
- IL6 -174 G/CHigher inflammatory tone
- CYP2D6 Normal metabolizerExpected exposure
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumNormal
- EnterobacteriaceaeHigh
- HRV
- 38 ms
- Sleep
- 7.8 h
- Steps
- 3,881
- Resting HR
- 65 bpm
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
- Log the daily check-in; one line is enough
- A 15-minute walk after lunch
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.
| Patient | Similarity | Baseline | Intervention | Outcome | Response today |
|---|---|---|---|---|---|
| P-03264 | 42% | S17 | AD-05 | improved | 51 |
| P-03358 | 37% | S06 | AD-05 | improved | 51 |
| P-03052 | 30% | S14 | AD-05 | no change | 77 |
| P-03108 | 45% | S01 | BR-03 | no change | 60 |
| P-03181 | 44% | S11 | BR-03 | improved | 65 |
| P-03228 | 39% | S20 | BR-03 | no change | 68 |
| P-03283 | 33% | S11 | BR-03 | no change | 50 |
| P-03462 | 32% | S20 | BR-03 | improved | 77 |
| P-03213 | 31% | S16 | BR-03 | improved | 47 |
| P-03418 | 31% | S18 | BR-03 | improved | 40 |
| P-03207 | 33% | S16 | CR-01 | improved | 72 |
| P-03001 | 31% | S14 | CR-01 | improved | 53 |