Patient P-03410
Immune response 37 at the day-84 endpoint (observed).
Not responding because: rapid metabolizer (under-exposure); no butyrate producers (4 keystone absent, butyrate 494 CPM); Enterococcus faecium above range (LPS load); low diversity (Shannon 2.8). The drug never had the barrier to work with.
Drift detected on day 24 (HRV −8 ms, resting HR +6 bpm, sleep −0.7 h, immune-related gi adverse events +7, inflammatory load +9); nothing reported yet — the window to act is open.
4 of 4 scheduled doses in the last 60 days are biologically confirmed (100%). Dose signature: resting HR +4 bpm, HRV −9 ms.
Trajectory is stable relative to similar patients; keep the current content.
- 🍽Keep meals regular; three to four moderate portions spaced through the day
- 🍽Include a cooked vegetable portion with each main meal
- ✓Log the daily check-in; one line is enough
- ✓Keep the current walking rhythm
- 💊Take the scheduled dose as agreed with your care team
- 💊No additional supplements this week
Adherence is not the problem.
sleep quality falling under 35 while GI rises
P-03410 is on day 146 of ONX-7 (NR, baseline S20): response unstable, tolerance deteriorating, GI favorable. Over 14 days response moved -1 and GI 0; discontinuation risk is 20%. The state is between basins, heading drifting, after diverging from the model on day 24.
Biology sets the gain: Low microbial diversity; butyrate capacity 43/100, diversity 2.8. Pushing it down: Low butyrate capacity (-34.1), Enterococcus faecium 11.165% (LPS load) (-33.5), 4 keystone species absent (-25.5). Pulling it up: Protein (supports) (+23.9). From the daily log: protein -5.2 GI next day, alcohol +4.9 GI next day, fat +4 GI next day.
No action has been tried yet.
No action is indicated now; the trajectory is stable relative to similar patients.
Trajectory
Baseline → today → 30-day prediction · hover a day for signals and events- Day 0 ONX-7 started — Baseline state S20
- Day 24 Trajectory diverged from prediction — Observed response fell below the model's expected path.
What changed?
Trajectory began diverging from predicted response on Day 24.
- Toxicity+6
- Inflammatory activity+2
- Treatment adherence+2
What helped?
No interventions yet.
Daily trackers
Asset settingsThe trackers this program marks as important, last 14 days vs the 14 before.
Heading drifting · 58 from the failing basin, 51 from restoration.
- No untried action with strong evidence. Compose one from primitives.
- More proteinGI -5.2 next day on high-intake days · n 24
- AD-05 Adherence Supportonly 38% improved among 8 similar
- Keep alcohol lowGI +4.9 next day on high-intake days · n 18
- Keep fat lowGI +4 next day on high-intake days · n 17
Next-day GI change on high-intake vs low-intake days, last 60 days. Attribution from this patient's own log; sensitivity set by their biology.
- Protein-5.2supporter · 95%
- Alcohol+4.9detractor · 95%
- Dietary fat load+4detractor · 95%
- Histamine load-1.3no signal · 27%
- Lactose-0.4no signal · 15%
- Caffeine0no signal · 15%
DeepGene damage signature
The metagenomic + host-DNA read-out that initializes this patient's biology and, on retest, measures whether the steering worked.
- 1 opportunist above range: Enterococcus faecium
- 4 keystone species absent
- Shannon 2.19 (expected ≥ 3)
- 6 resistance genes
- Tissue recycling index 47
Biological layers
Which pathways look influenced, and by which layer of this person's biology.
- Butyrate / short-chain fatty acid production ↓60
- MicrobiomeButyrate capacity 43/100
- MicrobiomeF. prausnitzii depleted
- Mucosal barrier integrity ↓30
- MicrobiomeAkkermansia low → thinner mucus layer
- Inflammatory signalling ↑15
- WearableHRV 36 ms, trending down
- CYP2D6 Rapid metabolizerExpected exposure
- MTHFR C677TReduced folate turnover
- Akkermansia muciniphilaLow
- Faecalibacterium prausnitziiLow
- Bacteroides fragilisNormal
- Bifidobacterium longumLow
- EnterobacteriaceaeNormal
- HRV
- 36 ms
- Sleep
- 7.7 h
- Steps
- 9,954
- Resting HR
- 55 bpm
What this patient sees in NostraAI
The content that steers the trajectory: what to eat, what to do, what to take.
- Keep meals regular; three to four moderate portions spaced through the day
- Include a cooked vegetable portion with each main meal
- Add one soluble-fibre source (oats, cooked carrots, banana) to breakfast
- Avoid known triggers for now: fried or oily food, dairy, alcohol
- Log the daily check-in; one line is enough
- Keep the current walking rhythm
- Keep the sleep window steady
- Keep hydration steady: small amounts through the day rather than large volumes at once
- Take the scheduled dose as agreed with your care team
- No additional supplements this week
- Fictional demo item: continue vitamin D as before
284 biologically similar trajectories
Black: this patient. Green: similar patients whose intervention worked. Orange: similar patients where it did not.