700 patients110,866 observations180 daysLIVE

49 trajectories in Delayed loss of response

Trajectories

Synthetic demo data

All Strong responders · 180 Moderate responders · 160 Non-responders · 70 Early toxicity · 84 Late toxicity · 42 Delayed loss of response · 49 Resilient responder · 25 High response / high intolerance · 90

Mean lived trajectory vs baseline model

days with fewer than 10 patients are cut

solid = observed · dashed = predicted

Individual trajectories, highest risk first

P-02525D170 · risk 50%

UnstableDeterioratingresp 32

P-02308D157 · risk 35%

UnstableDeterioratingresp 27

P-02198D180 · risk 30%

UnstableDeterioratingresp 33

P-02232D103 · risk 27%

FavorableDeterioratingresp 65

P-02087D146 · risk 25%

UnstableFavorableresp 40

P-02161D172 · risk 23%

UnstableDeterioratingresp 28

P-02517D173 · risk 21%

ImprovingDeterioratingresp 48

P-02258D177 · risk 18%

UnstableDeterioratingresp 26

P-02291D179 · risk 15%

UnstableImprovingresp 30

P-02280D124 · risk 13%

DecliningFavorableresp 50

P-02625D168 · risk 12%

UnstableFavorableresp 36

P-02687D170 · risk 9%

UnstableImprovingresp 42