700 patients110,866 observations180 daysLIVE

70 trajectories in Non-responders

Trajectories

Synthetic demo data

All Strong responders · 180 Moderate responders · 160 Non-responders · 70 Early toxicity · 84 Late toxicity · 42 Delayed loss of response · 49 Resilient responder · 25 High response / high intolerance · 90

Mean lived trajectory vs baseline model

days with fewer than 10 patients are cut

solid = observed · dashed = predicted

Individual trajectories, highest risk first

P-02636D173 · risk 59%

UnstableDeterioratingresp 30

P-02662D101 · risk 45%

UnstableDeterioratingresp 20

P-02680D173 · risk 38%

UnstableDeterioratingresp 29

P-02603D130 · risk 30%

UnstableDeterioratingresp 15

P-02114D168 · risk 27%

UnstableDeterioratingresp 29

P-02407D179 · risk 23%

UnstableDeterioratingresp 30

P-02085D177 · risk 21%

UnstableImprovingresp 26

P-02092D179 · risk 20%

UnstableDeterioratingresp 34

P-02246D180 · risk 19%

UnstableFavorableresp 31

P-02422D147 · risk 18%

UnstableImprovingresp 30

P-02678D179 · risk 17%

UnstableImprovingresp 28

P-02201D172 · risk 15%

UnstableImprovingresp 30