700 patients110,866 observations180 daysLIVE

42 trajectories in Late toxicity

Trajectories

Synthetic demo data

All Strong responders · 180 Moderate responders · 160 Non-responders · 70 Early toxicity · 84 Late toxicity · 42 Delayed loss of response · 49 Resilient responder · 25 High response / high intolerance · 90

Mean lived trajectory vs baseline model

days with fewer than 10 patients are cut

solid = observed · dashed = predicted

Individual trajectories, highest risk first

P-02123D166 · risk 76%

ImprovingUnstableresp 62

P-02136D180 · risk 71%

FavorableUnstableresp 63

P-02111D176 · risk 70%

StableUnstableresp 51

P-02444D168 · risk 68%

StableUnstableresp 59

P-02205D169 · risk 66%

ImprovingUnstableresp 57

P-02367D176 · risk 62%

ImprovingUnstableresp 67

P-02034D175 · risk 58%

FavorableUnstableresp 61

P-02151D172 · risk 55%

StableImprovingresp 49

P-02591D169 · risk 55%

ImprovingImprovingresp 68

P-02334D156 · risk 51%

ImprovingStableresp 66

P-02154D164 · risk 48%

ImprovingDeterioratingresp 57

P-02240D173 · risk 42%

ImprovingImprovingresp 57