700 patients110,866 observations180 daysLIVE

84 trajectories in Early toxicity

Trajectories

Synthetic demo data

All Strong responders · 180 Moderate responders · 160 Non-responders · 70 Early toxicity · 84 Late toxicity · 42 Delayed loss of response · 49 Resilient responder · 25 High response / high intolerance · 90

Mean lived trajectory vs baseline model

days with fewer than 10 patients are cut

solid = observed · dashed = predicted

Individual trajectories, highest risk first

P-02122D136 · risk 56%

DecliningDeterioratingresp 42

P-02395D170 · risk 35%

ImprovingDeterioratingresp 57

P-02645D176 · risk 27%

StableDeterioratingresp 56

P-02219D173 · risk 23%

ImprovingDeterioratingresp 60

P-02037D178 · risk 20%

StableFavorableresp 53

P-02183D177 · risk 18%

ImprovingFavorableresp 60

P-02033D172 · risk 17%

ImprovingDeterioratingresp 51

P-02147D168 · risk 15%

DecliningFavorableresp 58

P-02072D170 · risk 14%

StableFavorableresp 56

P-02295D171 · risk 13%

ImprovingImprovingresp 50

P-02479D161 · risk 11%

StableImprovingresp 48

P-02169D179 · risk 8%

DecliningImprovingresp 43