700 patients110,866 observations180 daysLIVE

90 trajectories in High response / high intolerance

Trajectories

Synthetic demo data

All Strong responders · 180 Moderate responders · 160 Non-responders · 70 Early toxicity · 84 Late toxicity · 42 Delayed loss of response · 49 Resilient responder · 25 High response / high intolerance · 90

Mean lived trajectory vs baseline model

days with fewer than 10 patients are cut

solid = observed · dashed = predicted

Individual trajectories, highest risk first

P-02039D138 · risk 96%

UnstableUnstableresp 38

P-02505D177 · risk 96%

StableUnstableresp 45

P-02575D94 · risk 96%

FavorableUnstableresp 73

P-02643D151 · risk 96%

ImprovingUnstableresp 46

P-02670D153 · risk 94%

DecliningUnstableresp 45

P-02511D168 · risk 90%

DecliningUnstableresp 51

P-02124D179 · risk 83%

UnstableUnstableresp 31

P-02445D158 · risk 79%

StableUnstableresp 43

P-02018D168 · risk 74%

ImprovingUnstableresp 46

P-02316D177 · risk 73%

ImprovingUnstableresp 51

P-02504D164 · risk 67%

StableStableresp 52

P-02674D123 · risk 64%

StableImprovingresp 48