700 patients110,866 observations180 daysLIVE

160 trajectories in Moderate responders

Trajectories

Synthetic demo data

All Strong responders · 180 Moderate responders · 160 Non-responders · 70 Early toxicity · 84 Late toxicity · 42 Delayed loss of response · 49 Resilient responder · 25 High response / high intolerance · 90

Mean lived trajectory vs baseline model

days with fewer than 10 patients are cut

solid = observed · dashed = predicted

Individual trajectories, highest risk first

P-02576D153 · risk 57%

DecliningDeterioratingresp 61

P-02371D169 · risk 35%

FavorableDeterioratingresp 64

P-02063D170 · risk 31%

StableDeterioratingresp 59

P-02673D160 · risk 29%

DecliningDeterioratingresp 60

P-02042D168 · risk 25%

FavorableDeterioratingresp 66

P-02260D174 · risk 22%

DecliningFavorableresp 60

P-02338D175 · risk 20%

StableFavorableresp 57

P-02550D169 · risk 19%

ImprovingImprovingresp 70

P-02335D135 · risk 17%

FavorableFavorableresp 70

P-02356D169 · risk 15%

ImprovingFavorableresp 69

P-02540D169 · risk 14%

ImprovingFavorableresp 64

P-02080D175 · risk 11%

ImprovingImprovingresp 59